イオン交換体による放射性ストロンチウムの吸収阻止

概要

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Some of the present investigators already reported on the inhibitory effect of strong cation exchange resins on radiostrontium absorption in the gastrointestinal tracts at the 3rd Japan Isotope Conference. In the present work further investigations were made on sulfonated polystyrene ionexchange resin, phosphonated polystyrene ionexchange resin, and sulfomethylcellulose ion exchanger. I. In vitro experiments : The ion exchangers were shaken in suspension with the solution of radiostrontium in flasks containing calcium salt in several concentrations. Adsorption of radiostrontium by ion exchangers increased with the decrease in the concentration of calcium in the medium. In a medium of physiological concentration (10 m mole) of calcium salt sulfonated polystyrene resin rapidly adsorbed more than 98% of radiostrontium. II. Animal experiments : Sodium, calcium, and strontium forms of the resins were administered to rats, mixed in their diet containing radioactive strontium in the form of calcium strontium carbonate. Calcium form of fulfonated polystyrene resin is the most effective in inhibiting gastrointestinal absorption of radiostrontium. The larger the amount of the resin in the diet, the larger was the amount of radiostrontium in the feces. A diet containing the resin of the calcium form in 40% of the diet inhibited the absorption to the level of 1/2 to 1/8 of the control group.
社団法人日本薬学会の論文
1967-06-25