実験的Osteolathyrismに対するCalcitoninの作用(第1報) : Aminoacetonitrile処理による骨代謝の変動

概要

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The changes in the bone metabolism by the administration of aminoacetonitrile to young rats were examined. Biochemical analyses of the bone of young rats fed with 0.1% dietary aminoacetonitrile for 3-9 days showed that an increase in the solubility of collagen constituted the initial alteration. Then serum calcium concentration and serum alkaline phosphatase activity were increased after 9 days of aminoacetonitrile treatment. At the same time, there was an increase in the release of total hydroxyproline from metaphyses in vitro. Increase of dietary aminoacetonitrile from 0.1% to 0.2% further increased the amount of soluble collagen. Serum alkaline phosphatase activity and the release of total hydroxyproline from metaphyses were also increased. On the contrary, serum calcium concentration decreased, while the formation of multiple exostoses was observed. After 9 days of 0.2% dietary aminoacetonitrile treatment there was a great increase in the urinary total hydroxyproline excretion, indicating an increased rate of collagen turnover. Administration of calcitonin to lathyritic rats showed a significant hypocalcemic effect and the effect of lowering serum alkaline phosphatase activity.
社団法人日本薬学会の論文
1971-05-25