増殖性炎症組織におけるムコ多糖および糖タンパクの経日的変化とこれらヘキソサミン含有物質に対する抗炎症薬の作用

概要

論文の詳細を見る
Hexosamine-containing substances, acidic glycosaminoglycans and glycoproteins, extracted from carrageenin granuloma obtained from the rat 4,6,8,10,and 16 days after the injection of carrageenin solution, were studied. Considerable changes were observed in both fractions; during the evolution of granulomatous tissue from 4th to 6th day of hexosamine and uronic acid content in glycosaminoglycans reached a peak and then decreased gradually whereas glycoproteins gradually increased from 6th to 16th day. The effect of anti-inflammatory drugs on the carrageenin granuloma was tested for their inhibitory action on the content of hexosamine-containing substances by means of their daily local injection into pre-formed granuloma pouch during 6th to 9th day. A steroidal drug, betamethasone, reduced the content of both hexosamime-containing substances, while non-steroidal drugs, phenylbutazone and D-penicillamine, did not reduce the content significantly. Chondroitin sulfate isomers were also analyzed by the chondroitinase method. Chondroitin sulfate-B decreased strikingly compared with chondroitin sulfate-A by the treatment of a rat with betamethasone. Effect of this steroidal drug on the metabolism of glycosaminoglycans labeled with ^<35>S was investigated. Betamethasone markedly inhibited the synthesis of sulfated glycosaminoglycans and considerably inhibitid the degradation of glycosaminoglycans.
公益社団法人日本薬学会の論文
1974-09-25