神経・筋疾患の病態生理に関する研究(第1報) : 健常骨格筋におけるグリコーゲン代謝, 特にヒラメ筋および外側広筋について

概要

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This preliminary study was designed to assess the glycogen metabolism of neuro-muscular diseases using rabbits. The results showed that the enzymatic capacity of glycogen synthesis in slow muscles (S) is higher than that of fast muscles (F), however, glycogenolysis was found to be reversed in data. The activity of cyclic AMP-deoendent protein kinase (kinase A) is S was higher than that of F. Active form ratios of glycogen-metabolizing enzymes in S and F were influenced by this kinase A. Since the activity of protein phosphatase in S was higher than that of F, S was throught to be regulated to a larger extent by kinase A.These investigations were found to be useful in evaluating the physiological characteristics of muscle and neuro-muscular diseases.
社団法人日本リハビリテーション医学会の論文
1989-01-18