輸液中の光不安定薬物に対するポリエチレンテレフタレートフィルムの遮光効果

概要

論文の詳細を見る
Protective effect of polyethylene telephthalate (PET) film was studied, using Methylcobalamin (CH_3・B_13) and Furosemide which were unstable under the photoradiation. CH_3・B12 was mixed in the 5% glucose solution and dript (2.8ml/min) from the plabottle setted for transfusion under fluorescent lamps, where the illuminance at the top of the bottle was 1,000 lux in a laboratory or a ward. When dripping and irradiation started simultaneously, no CH_3・B_12 could be detected in the drops 30 min later; whereas 75% and 50% of CH_3・B_12 were found after 30 and 120 min respectively, when plabottle was shielded with PET film. This protective effect was observed in a ward as well. Further experiment without dripping showed that CH_3・B_12 was linearly degraded with time by irradiation, and about 80% of it remained after 60 min when plabottle was shielded with PET film; whereas 45 and 20% of CH_3・B_12 remained after 5 and 10 min, respectively when PET film was not used. These data indicated that the rate costant of photogradation of CH_3・B_12 in plabottle shielded with PET film was less than 1/40 of that without PET film. Moreover, furosemide in plabottle shielded with PET film was not almost photodegraded after irradiation for 4hr under sunlight, but not detected when no PET film was used. These results indicate that PET film was clinically very useful for the protection against the photodegradation of CH_3・B_12 or furosemide in plabottle for transfusion.
日本医療薬学会の論文
1990-06-20

輸液中の光不安定薬物に対するポリエチレンテレフタレートフィルムの遮光効果

スポンサーリンク

概要

著者

関連論文

スポンサーリンク