桃核承気湯エキス顆粒剤と煎剤との比較

概要

論文の詳細を見る
Comparison between the original decoctions of "Toukakujohki-toh," one of the commonly prescribed formulas in oriental medicine, and the granules of the extracts of 6 commercially available brands was studied on the following subjects; 1) Contents of cinnamic aldehyde, cinnamic acid and glycyrrhizic acid; 2) TLC profiles of the freeze-dried decoction and of the granules extracted with n-hexane, chloroform and methanol; 3) Effects on blood coagulation and fibrinolysis in vitro. In all of the six brands, the total amount of extracts in the daily dose was smaller than 1/3 of the original decoctions. Especially, volatile compounds in the granules such as cinnamic alehyde and cinnamic acid were remarkably reduced as compared with those in the decoctions. The TLC profiles of 2 preparations, decoctions and granules also showed a difference from each other. It was indicated that the effects of the granules of Toukakujohki-toh extracts on coagulation measured in prothromdin time and activated partial thromboplastin time and on fibrinolysis of urokinase measured by fibrin plate method were only 10% of the effects of original decoctions.
日本医療薬学会の論文
1984-02-20