Macrophage Procoagulant Activityに及ぼす漢方方剤煎液の影響(第1報)

概要

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The effects of decoctions of four Kanpo-prescriptions (Keishi-Ni-Eppi-Ittoh-Ka-Ryoh-Jutsu-Bu, Keishi-Ka-Jutsu-Bu-Toh, Keishi-Shakuyaku-Tchimo-Toh, and Yokuinin-Toh), which are widely used in Japan for the therapy of rheumatoid arthritis, on macrophage procoagulant activity was investigated. Peritoneal exudate cell of guinea pig was used as a macrophage source. These four decoctions were added to the macrophage suspensions in vitro, and each suspension was incubated for 14 h at 37℃. Macrophage procoagulant activity was measured by the method similar to that of determination of the recalcification time of the plasma. It was found that the decoctions of these four Kanpoprescriptions potentiated remarkably the macrophage procoagulant activity. In addition, we examined similarly the effect on the macrophage procoagulant activity of 18 kinds of crude drug including the constituents of these four prescriptions, and the decoctions of three kinds of crude drug, Byakujutsu, Sohjutsu, and Maoh, had apparent enhancing effect on it. Since every four Kanpo-prescription described above includes Byakujutsu or Maoh, their potentiating activity on macrophage procoagulant activity was dependent on the active substances of Byakujutsu and Maoh.
社団法人日本薬学会の論文
1984-09-25