注射剤添加物の凝固・線溶系に及ぼす影響

概要

論文の詳細を見る
Effects of six kinds of additives in injections, i. e. benzyl alcohol, HCO-60,macrogol 4000,urethan, sodium bisulfite and sodium sulfite, on the blood were investigated, and the following results were obtained ; 1) In the concentrations of additives contained in injections benzyl alcohol inhibited the platelet aggregation and the inorganic salts had the inhibitory effects on both the blood coagulational and fibrinolytic phenomena. The action of sodium bisulfite on the blood was recognized to be based on pH and that of sodium sulfite to be ascribed to SO_3^<2->. 2) The injections which contain both benzyl alcohol and sodium bisulfite as additives are commercially available. However, they are not evaluated to be desirable injections from the standpoints of hematology, especially of coagulation, fibrinolysis and platelet aggregation.
社団法人日本薬学会の論文
1983-01-25