アミノフィリン末を賦形する際に用いるデンプンの評価

概要

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The potato starch has been used as excipients on dispending the aminophylline powder in our hospital pharmacy. In our test about the error of dividing weight used automatic dividing packing machine model KC805-K90 (Konishi), the coefficient of variation (C.V.) of aminophylline mixed potato starch was more than 10% for 21 subpacks of 0.5g. Then, we studied the relation between the dividing time and the error of dividing weight, and the rate of loss. Furthermore, we examined the physical properties of each starch and the chemical incompatibility on mixing aminophylline and each starch. The rice starch revealed the smallest C.V. value (%) in each starch and was not changed chemically when it was mixed with the aminophylline powder. These results suggest that the rice starch is the most useful excipients from a dispending point of view.
日本医療薬学会の論文
1989-02-20