イオパミドールを配合したオレイン酸エタノールアミン注射液の調製

概要

論文の詳細を見る
Ethanolamine oleate injection containing 30% iopamiron 300 (30% IP300-EO) has been previously prepared for endoscopic sclerotherapy of esophageal varices on X-ray TV monitor. However, the ability of fluoroscopic visualization of this sclerosing agent was slightly insufficient in clinical use. We prepared ethanolamine oleate injection containing 30% iopamiron 370 (30% IP370-EO), and measured the physical characteristics such as viscosity and osmotic pressure of this agent. The ability of visualization was observed in patients with esophageal varix by X-ray. The viscosity, which was inversely related to the injectability into varices, of 30% IP370-EO was relatively low and its osmotic pressure was almost the same as that of normal saline. 30% IP370-EO was easily injected into varices. Better fluoroscopic visualization was obtained by intravariceal injection with 30% IP370-EO than with 30% IP300-EO. These results suggest that 30% IP370-EO is more useful agent for endoscopic sclerotherapy of esophageal varices.
日本医療薬学会の論文
1988-08-20