食道静脈瘤に対する内視鏡的硬化栓塞療法剤の検討 : イオメプロールを配合したオレイン酸モノエタノールアミン注射液について

概要

論文の詳細を見る
Monoethanolamine oleate injection containing 50% Iopamiron 370(50% IP370-EO) has been previously prepared for endoscopic sclerotherapy of esophageal varices on X-ray TV monitor. However, the dischargeable pressure of this sclerosing agent was slightly insufficient during clinical use. We therefore prepared monoethanolamine oleate injection containing 50% Iomeron 350(50% IM350-EO) or 75% Iomeron 350(75%IM350-EO), and measured the physical characteristics such as viscosity and osmotic pressure of this agent. The time required to discharge a given volume of each agent through a syringe, a tube and a puncture needle under the pressure of 2 kg/2.6cm^2 was measured. The ability to visualize this process was observed in patients with esophageal varices by X-ray. The viscosity, which was inversely related to the injectability into varices, of 50% IM350-EO was lower than that of 50% IP370-EO. The viscosity of 75% IM350-EO was also lower than that of 75% IP370-EO. The osmotic pressure ratio of 50% IM350--EO and 75% IM350_EO were lower than those of 50% IP370-EO and 75% IP370-EO, respectively. The time required to discharge 50% IM350-EO was the shortest. Good fluoroscopic visualization was obtained in all preparations. Better contrast was obtained in the cardiac zone with 75% IM350-EO than with 75% IP370-EO. These results suggest that 50% IM350-EO and 75% IM350-EO are more useful agents for endoscopic sclerotherapy of esophageal varices.
日本医療薬学会の論文
1996-10-10

食道静脈瘤に対する内視鏡的硬化栓塞療法剤の検討 : イオメプロールを配合したオレイン酸モノエタノールアミン注射液について

スポンサーリンク

概要

著者

関連論文

スポンサーリンク