アスコルビン酸ジパルミテートの安定性におよぼす軟膏及び軟膏基剤の影響

概要

論文の詳細を見る
High-speed liquid chromatography (HSLC) was used for the stability test of ascorbic acid dipalmitate (AsA-DP) in ointments and ointment bases, under the following conditions : model, JASCO FLC-350 ; detector, UVIDEC-I ; wavelength, 254 nm ; column, ZORBAX ODS (4.6 x 250mm) ; mobile phase, Me0H ; flow rate, 1m1/min ; Pressure, 100kg/cm^2 ; chart speed, 0.5 cm/min (at room temperature). The extracted AsA-DP was directly injected into the HSLC column. The amount of AsA-DP was determined from the peak height on the chromatogram. Absorption ointment, hydrophilic ointment, hydrophilic petrolatum, and 14 kinds of ointment bases containing 1% AsA-DP were exposed to air at 40°where their stability to oxidation was measured with HSLC. The results were as follows : 1) The decomposition in ointments and ointment bases was pseudo-first order. 2) AsA-DP in ointments was stable in order of hydrophilic petrolatum, hydrophilic ointment and absorption ointment. 3) AsA-DP in stearyl alcohol, cetanol, and sorbitan sesquioleate was unstable, while that in white petrolatum, liquid paraffin, and stearic acid was very stable. 4) The decomposition product of AsA-DP in ointments and ointment bases was ascorbic acid-6-mono-palmitate.
日本医療薬学会の論文
1982-02-20