高カロリー輸液中のビタミンの安定性に及ぼす徴量元素の影響

概要

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We investigated the stability of vitamins in hyperalimentation fluids adding trace minerals. Test samples were prepared by adding trace minerals to three kinds of hyperalimentation different dextrose/electrocyte concentrations. The time-course of the potencies of vitamins and pH of the test samples with and without trace minerals were determined under three different conditions as follows: room temperature with shield or exposure of light and cold dark place. Total vitamin C content including oxidized dehydroascorbic acid was determined, and these results showed that the residual rate of the total vitamin C was decreased with the addition of trace minerals under room temperature with shield of light. The effect of the addition of trace minerals was also noted markely in the test samples under cold dark place. On the other hand, we observed no direct effect on stabilities of vitamin B_1, B_2, B_8, folic acid. A, E, and K_1, by adding trace minerals.
日本医療薬学会の論文