Solubilization Behavior of Estriol in an Aqueous Solution of Pluronic L-64 as a Function of Concentration and Temperature

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The solubilization of estriol was studied in an aqueous solution of a poly(ethylene oxide)/poly(proplylene oxide)/poly(ethylene oxide) triblock copolymer (pluronic L-64).The solubility of estriol increased with increasing pluronicL-64 concentrations and temperatures. Two clear transition points were found on the solubility curves at 30 and 40℃. These two transition points were in good agreement with the 2nd critical micelle concentration and the change points of the micellar structure determined by our previous report. Furthermore, the thermodynamic parameters of estriol solubilization were also discussed.
公益社団法人日本薬学会の論文
1994-06-15