口腔乾燥症状(ドライマウス)の改善を目的とした新規スプレーの臨床評価

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The use of a new spray designed to alleviate xerostomia symptoms was evaluated in the clinical setting. Two kinds of spray were compared, one of them containing 0.1% sodium hyaluronate (HA) and the other no HA. The other ingredients of the 2 sprays were 0.1% sodium alginate (ALG), 0.3% of a commercial bitter-masking powder made from lecithin (Benecoat BMI-40) and 0.08% lemon essence. Both sprays were stored under various conditions for various periods, and the microbial enumeration test was conducted for some storage conditions. We also prepared a questionnaire for patients based on the literature and consultation with a dentist to score their xerostomia symptoms. The taste, smell, degree of irritation and texture of the 2 sprays were evaluated by 21 oral surgery outpatients complaining of xerostomia. Eighteen of the 21 patients completed the questionnaire before and after using one of the sprays for 7 days. The storage conditions were set at 14 days at room temperature or in a refrigerator. The questionnaire consisted of 15 items relating to xerostomia symtoms, 5 to ADL and 2 items to QOL. There was an improvement in the xerostomia symptomrelated item of "drink water frequently, carry water around" for both patients using the 0.1% HA spray and the one not containing HA. This was attributed to the effect of ALG on mucous membranes. On examining total scores by underlying disease, improvement was noted for patients with xerostomia as a complication of oral ulcer, glossitis, glossodynia or lichen planus. The 2 sprays may therefore be effective in alleviating symptoms of xerostomia.
日本医療薬学会の論文
2008-03-10

口腔乾燥症状(ドライマウス)の改善を目的とした新規スプレーの臨床評価

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