ダブルバッグ型 TPN 液に配合したビタミンの安定性

概要

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A new double-chambered plastic bag for total parenteral nutrition (TPN) solution, PN-twin^<[○!R]>, has become commercially available. One PN-twin^<[○!R]> chamber termed layer I , contains dextrose and electrolytes while the other chamber, layer II, consists of amino acids. Test samples were prepared by adding vitamins and trace minerals to the mixtures of layers I and II solutions, and only to a layer I solution. The stabilities of vitamins A, B_1, B_2, B_6, C, E, folic acid (FA) and K_1 were studied under three different conditions: room temperature in a dark place, room temperature with light exposure, and cold in a dark place. The residual rates of vitamins B_2, C and K_1 in the layers I and II solution mixture stored at room temperature with light exposure for 48 hours dropped to under 63%. With the addition of trace minerals into the test samples in a cold, dark place, the residual rate of vitamin C decreased significantly. Also, the residual rates of vitamin B_1 in the layer 11 solution decreased rapidly. After storing at room temperature for 48 hours and/or in a cold, dark place for 7 days, the residual rates of vitamin B_1 fell to below 6%. These findings suggested that the addition of vitamins to PN-twin^<[○!R]> should be avoided before the two separate chambers and connected.
日本医療薬学会の論文
1995-08-10