α, β-不飽和アミノ酸を利用したペプチドの間組合 : カルボキシ末端アミドを持つペプチド

概要

論文の詳細を見る
A new and milder method for solid-phase synthesis of peptide amide is described. A peptide chain with, ΔAla at the C-terminal position was assembled on Merrifield resin. The peptide was cleaved from the support at the ΔAla residue to give peptide amide by treatment with HCl in glacial acetic acid in the presence of an equivalent amount of water. Thus, a tripeptide amide, H-L-Leu-L-Ala-Gly-NH_2,was synthesized starting from Boc-Gly-ΔAla-resin in high yield and in high purity. The applicability and advantage of the method were demonstrated by he synthesis of two biologically active peptide amides, thyrotropin-releasing factor and the N-terminal tripeptide amide of luteinizing hormone/follicle stimulating hormone-releasing factor, pyro-L-Glu-L-His-L-Trp-NH_2.
福岡女子大学の論文
1983-01-30