エナメル芽細胞におけるCBFA-1/Ranx2の局在

概要

論文の詳細を見る
Mutations in Runx 2/CBFA-1 (Core binding protein A-1) cause cleidocranial dysplasia (CCD), an autosomal dominant disorder in humans and mice characterized by defective bone formation. CCD also results in dental defects. Runx 2 is a critical transcriptional regulator of osteoblast differentiation, and also has an important role for this molecule in the tooth formation. However, little is known about function in the ameloblasts of the maturation stage. Therefore, Runx 2 localizations of ameloblasts were investigate in ameloblasts during amelogenesis in rat incisor, by means of immunohistochemistry. In the transitional stage, the ameloblasts and the outer enamel epithlium showed an intense immunoreactivity. The periodicaly stained bands were appeared in the maturation stage. The periodic bands were corresponded with the transitional region of ameloblastic modulation. During the modulation, immunoreactivity was detected in the ruffled-ended ameloblasts and the cells of pappilary layer. Runx 2 plays an important role in the differentiation of the amelobasts and enamel formation.
2003-12-25