デスモイド型およびDupuytren型線維腫症の核DNA量解析による増殖能の比較

概要

論文の詳細を見る
Fibromatosis of the soft tissue is a rare tumor or tumor-like lesion. However, occasional cases have recurrence and invasive pattern to surrounding tissue. For the objective evaluation of proliferative activity, twelve cases of histopathologically diagnosed fibromatoses including desmoid type and Dupuytren type were studied by flow cytometric DNA content analyses. The proliferative index (S+G_2+M fraction) in invasive pattern was significantly higher than that in non-invasive pattern of fibromatoses. Aneuploidy was detected in two cases (16.7%) of fibramaotses. The frequency of DNA aneuploidy was not significant in either invasive pattern or non-invasive pattern of fibromatoses. These results suggest that the proliferative index is likely to be implicated in the invasive patterns and recurrence.
香川県立保健医療大学の論文