体腔液細胞診における腺癌細胞と反応性中皮細胞の免疫細胞化学的検討

概要

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Cytological study of body fluid is very important to determine whether or not such fluid is caused by neoplasm. The cytological and clinical diagnoses are often difficult to discriminate between reactive mesothelium in inflammatory disease and malignant cells, especially adenocarcinoma. We assessed some molecular markers such as HBME-1, Calretinin, MOC-31, Thrombomodulin, Ber-EP4, CEA and EMA in fluid cytology in 24 cases of adenocarcinoma and in 17 cases of reactive mesothelium. The cases of adenocarcinoma showed stronger reactivity to MOC-31 and Ber-EP 4 than those of reactive mesothelium, whereas cases of the latter showed stronger reactivity to Calretinin than those with adenocarcinoma. The specificity of MOC-31 and Ber-EP 4 for adenocarcinoma was 100%. The specificity of Calretinin for reactive mesothelium was also 100%. The sensitivity of MOC-31 and Ber-EP 4 for adenocarcinoma was 100% and 91%, respectively. We concluded that immunocytochemical studies of these markers were very useful for the differential diagnosis of adenocarcinoma and reactive mesothelium in fluid cytology
香川県立保健医療大学の論文