<Originals>Stimulating Effect of Phenazine Methosulfate Plus NADH and Ascorbic Acid on Na^+, K^+-ATPase Activity in the Presence of Vanadate
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概要
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Effects of phenazine methosulfate+NADH and phenazine methosulfate+ascorbic acid on Na^+, K^+-ATPase activity were investigated, because Na^+-dependent active transport of amino acid and ouabain sensitive transport of Rb^+ were stimulated by phenazine methosulfate+ascorbic acid and phenazine methosulfate+NADH. Na^+, K^+-ATPase activity in NaI treated microsome isolated from guinea pig kidney was stimulated in the presence of vanadate by phenazine methosulfate+ascorbic acid and phenazine methosulfate+NADH. Vanadate has been known to be present in various mammalian cells at several hundred nM and to inhibit Na^+, K^+-ATPase activity potently at similar concentrations. Phenazine methosulfate alone and NADH alone did not stimulate Na^+, K^+-ATPase activity in the presence of vanadate, and ascorbic acid alone was less effective than phenazine methosulfate+ascorbic acid. K^+-dependent phosphatase activity was more sensitive to vanadate than Na^+, K^+-ATPase activity, and showed similar stimulation in the presence of vanadate by phenazine methosulfate+NADH and phenazine methosulfate+ascorbic acid. The prevention of vanadate inhibition of Na^+, K^+-ATPase by phenazine methosulfatel+NADH and phenazine methosulfate+ascorbic acid may explain the stimulation of active transports.
- 近畿大学の論文
- 1983-06-28
著者
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KANIIKE Kenichi
Second Department of Physiology, Kinki University School of Medicine
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MIYAMOTO Hiroshi
Second Department of Physiology, Kinki University School of Medicine
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MATSUO Osamu
Second Department of Physiology, Kinki University School of Medicine
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Kaniike Kenichi
Second Department Of Physiology Kinki University School Of Medicine
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Matsuo Osamu
Second Department Of Physiology Kinki University School Of Medicine
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Miyamoto Hiroshi
Second Department Of Physiology Kinki University School Of Medicine:(present Address) Department Of
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Miyamoto Hiroshi
Second Department Of Physiology Kinki University School Of Medicine
関連論文
- The Inhibitions by Vanadate on Na^+ K^+-ATPase and K^+-Dependent p-Nitrophenylphosphatase : Argument on the Relation to the Inhibition by Phenazine Methosulfate and VC
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- Na^+, K^+-ATPase Inhibiting Factor in Albumin : Vanadium Content and Inhibiting Ability on K^+-Dependent Phosphatase Activity
- Effect of Phenazine Methosulfate+Vitamine C on Ouabain Binding to Na^+, K^+-ATPase
- Kidney Na^+, K^+-ATPase in Stroke-Prone Spontaneously Hypertensive Rat
- Inhibition of Na^+, K^+-ATPase and K^+-Dependent Phosphatase Activities by Bovine Serum Albumin
- Stimulating Effect of Phenazine Methosulfate Plus NADH and Ascorbic Acid on Na^+, K^+-ATPase Activity in the Presence of Vanadate
- The Vanadate Inhibition on the Activities of Na^+, K^+-ATPase and K^+-Dependent Phosphatase in Microsomes from Kidney of Guinea Pig
- Inhibition of Ethanol on the Na^+, K^+-ATPase in the Microsome Preparation from Kidney of Guinea Pig
- Effect of Phenazine Methosulfate+Vitamine C on ADP Binding to Na^+, K^+-ATPase
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- Effect of PMS+VC on HCO^-_3-ATPase in the Kidney Microsomes from Guinea Pig
- Effect of Quercetin on Na^+, K^+-ATPase Activity and K^+-Dependent Phosphatase Activity in Microsomes Preparation from Guinea Pig Kidney