<Originals>Effect of Phenazine Methosulfate+Vitamine C on ADP Binding to Na^+, K^+-ATPase
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概要
- 論文の詳細を見る
[^<14>C] ADP binding to Na^+, K^+-ATPase in guinea pig kidney membrane preparations was investigated. The ADP binding which occurred without Mg^<2+> was inhibited by K^+. The inhibition by K^+ was antagonized by Na^+. The stimulation of ADP binding by Na^+ alone was not realized. The absence of Na^+ stimulation on the ADP binding may be due to a tissue or species difference. The addition of PMS (Phenazine methosulfate) 10μM+5mMVC (Vitamine C) resulted in a severe inhibition of ADP binding to Na^+, K^+-ATPase. PMS alone did not inhibit it significantly, but VC alone showed a significant inhibition. The PMS+VC inhibition on the ADP binding is attributable to the inhibition of the conversion from E_2 conformational state of the enzyme to E_1 state.
- 近畿大学の論文
- 1981-06-28
著者
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Kaniike Kenichi
Second Department Of Physiology Kinki University School Of Medicine
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KITANAKA Toichi
Second Department of Physiology, Kinki University School of Medicine
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Kitanaka Toichi
Second Department Of Physiology Kinki University School Of Medicine
関連論文
- The Inhibitions by Vanadate on Na^+ K^+-ATPase and K^+-Dependent p-Nitrophenylphosphatase : Argument on the Relation to the Inhibition by Phenazine Methosulfate and VC
- Na^+, K^+-ATPase Inhibiting Factor in Albumin : Effect of 4-(2-Pyridylazo)-Resorcinol on the Bovine Serum Albumin Inhibition of K^+-Dependent p-Nitrophenylphosphatase
- Na^+, K^+-ATPase Inhibiting Factor in Albumin : Vanadium Content and Inhibiting Ability on K^+-Dependent Phosphatase Activity
- Effect of Phenazine Methosulfate+Vitamine C on Ouabain Binding to Na^+, K^+-ATPase
- Kidney Na^+, K^+-ATPase in Stroke-Prone Spontaneously Hypertensive Rat
- Inhibition of Na^+, K^+-ATPase and K^+-Dependent Phosphatase Activities by Bovine Serum Albumin
- Stimulating Effect of Phenazine Methosulfate Plus NADH and Ascorbic Acid on Na^+, K^+-ATPase Activity in the Presence of Vanadate
- The Vanadate Inhibition on the Activities of Na^+, K^+-ATPase and K^+-Dependent Phosphatase in Microsomes from Kidney of Guinea Pig
- Inhibition of Ethanol on the Na^+, K^+-ATPase in the Microsome Preparation from Kidney of Guinea Pig
- Effect of Phenazine Methosulfate+Vitamine C on ADP Binding to Na^+, K^+-ATPase
- Effect of PMS+VC on the Activities of Na^+, K^+-ATPase, K^+-Dependent Phosphatase and Phosphorylation of Intermediate
- Effect of PMS+VC on HCO^-_3-ATPase in the Kidney Microsomes from Guinea Pig
- Effect of Quercetin on Na^+, K^+-ATPase Activity and K^+-Dependent Phosphatase Activity in Microsomes Preparation from Guinea Pig Kidney