Proteomic Identification of Serum Proteins Associated with Stress-Induced Gastric Ulcers in Fasted Rats
スポンサーリンク
概要
- 論文の詳細を見る
Several physical and psychological stresses frequently become triggers for gastrointestinal disorders such as ulcer. In this study, we tried to identify serum proteins as potential biomarkers for the evaluation of stress-induced gastric ulcer. By proteomic analysis using rats with gastric ulcer induced by water immersion and restraint (WIR) stress as an animal model, we found quantitative changes in several serum proteins, including creatine kinase muscle M chain (CK-M) and apolipoprotein A-IV (ApoA4) in the stressed rats. On western blotting and enzyme-linked immunosorbent assay (ELISA), we confirmed that serum CK-M was remarkably increased by WIR stress. However, ApoA4 appeared to be decreased by fasting, but not WIR stress, which is usually applied prior to WIR stress. The findings suggest that these two serum proteins might be useful as biomarkers, CK-M for stress-induced gastric ulcer and ApoA4 for starvation.
- 社団法人 日本農芸化学会の論文
- 2010-04-23
著者
-
内藤 博敬
静岡県大・環境科学研・環境微生物
-
内藤 博敬
静岡県立大学大学院生活健康科学研究科
-
Ohashi Norio
Graduate School Of Nutritional And Environmental Sciences And Global Coe Program Univ. Of Shizuoka
-
SAKAKIBARA Hiroyuki
Graduate School of Nutritional and Environmental Sciences, University of Shizuoka
-
SHIMOI Kayoko
Graduate School of Nutritional and Environmental Sciences, University of Shizuoka
-
Ohashi Norio
Laboratory Of Environmental Microbiology Institute For Environmental Sciences University Of Shizuoka
-
Naitou Hirotaka
Graduate School Of Nutritional And Environmental Sciences And Global Coe Program Univ. Of Shizuoka
-
Naitou H
Laboratory Of Environmental Microbiology Institute For Environmental Sciences University Of Shizuoka
-
Naitou Hirotaka
Graduate School Of Nutritional And Environmental Sciences University Of Shizuoka:global Coe Universi
-
Naitou Hirotaka
Laboratory Of Environmental Microbiology Graduate School Of Nutritional And Environmental Sciences U
-
Nakayama Tsutomu
Graduate School of Nutritional and Environmental Sciences and Global COE Program, University of Shiz
-
Kato Ayako
Graduate School Of Agriculture Kyoto University
-
Shimoi Kayoko
Global Coe Program Univ. Of Shizuoka
-
Nakayama Tsutomu
Graduate School Of Nutritional And Environmental Sciences And Global Coe Program Univ. Of Shizuoka
-
Nakayama T
School Of Food And Nutritional Sciences University Of Shizuoka
-
Kato Ayako
Graduate School Of Nutritional And Environmental Sciences And Global Coe Program University Of Shizu
-
NAMIOKA Makoto
Prima Meat Packers, Ltd.
-
AKIMOTO Masanobu
Prima Meat Packers, Ltd.
-
ISHII Takeshi
Graduate School of Nutritional and Environmental Sciences and Global COE Program, University of Shiz
-
Namioka Makoto
Prima Meat Packers Ltd.
-
Sakakibara Hiroyuki
Graduate School Of Nutritional And Environmental Sciences University Of Shizuoka
-
Ohashi Norio
Graduate School Of Nutritional And Environmental Sciences And Global Coe Program University Of Shizu
-
Shimoi Kayoko
Graduate School Of Nutritional And Environmental Sciences And Global Coe Program University Of Shizu
-
Nakayama Tsutomu
Graduate School Of Nutritional And Environmental Sciences And Global Coe Program University Of Shizu
-
Naitou Hirotaka
Graduate School Of Nutritional And Environmental Sciences And Global Coe Program University Of Shizu
-
Naitou Hirotaka
Institute For Environmental Sciences University Of Shizuoka
-
Ishii Takeshi
Graduate School Of Nutritional And Environmental Sciences And Global Coe Program University Of Shizu
-
Akimoto Masanobu
Prima Meat Packers Ltd.
-
Sakakibara Hiroyuki
Graduate School Of Nutritional And Environmental Sciences And Global Coe Program University Of Shizu
-
Ohashi Norio
Graduate School Of Integrated Pharmaceutical And Nutritional Sciences University Of Shizuoka
-
NAKAYAMA Tsutomu
Graduate School of Integrated Pharmaceutical and Nutritional Sciences, University of Shizuoka
-
SHIMOI Kayoko
Graduate School of Integrated Pharmaceutical and Nutritional Sciences, University of Shizuoka
-
Shimoi Kayoko
Graduate School of Integrated Pharmaceutical and Nutritional Sciences, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka 422-8526, Japan
関連論文
- 4-1 研究所一般公開(事業活動)
- 3-5 夏休み親子環境教室(地域環境啓発センター)
- C型慢性肝炎患者のインターフェロンβ療法におけるTT virus 重感染の影響
- PCR法を用いたTTウイルスDNAの同定と遺伝子型判定の検討
- Mutagenicity of Condensed Pyridazines with Different Substituents
- 河川中付着緑藻類の水質指標へ向けた遺伝学的解析法の検討(新規)(環境科学研究所推奨研究成果報告書)
- 水産養殖環境における細菌・ウイルス感染予防対策としての導入海水および希釈淡水処理法の検討(海外研修報告書)
- Proteomic Studies on Protein Oxidation in Bonito (Katsuwonus pelamis) Muscle
- Molecular Identification of Ehrlichia Species and 'Candidatus Neoehrlichia mikurensis' from Ticks and Wild Rodents in Shizuoka and Nagano Prefectures, Japan
- Characterization of Ehrlichia Species from Ixodes ovatus Ticks at the Foot of Mt. Fuji, Japan
- Molecular Identification of Ehrlichia Species and 'Candidatus Neoehrlichia mikurensis' from Ticks and Wild Rodents in Shizuoka and Nagano Prefectures, Japan
- Relationships between plasma and tissue transaminase activities in rats maintained under different feeding conditions
- Evaluation of superoxide anion radicals generated from an aqueous extract of particulate phase cigarette smoke by electron spin resonance using 5,5-dimethyl-1-pyrroline-N-oxide
- Evaluation of Superoxide Anion Radicals Generated from an Aqueous Extract of Particulate Phase Cigarette Smoke by Electron Spin Resonance Using 5,5-Dimethyl-1-pyrroline-N-oxide
- Determination of Hydrogen Peroxide by High-Performance Liquid Chromatography with a Cation-Exchange Resin Gel Column and Electrochemical Detector
- 対数増殖後期に発現が増大する Legionella pneumophila 仮想蛋白質の機能解析
- Proteomic Characterization of Angiogenic Endothelial Cells Stimulated with Cancer Cell-Conditioned Medium(Molecular and Cell Biology)
- 2P-234 細胞サイズのリン脂質ベシクル内におけるゲノムサイズDNAの高次構造変化(生体膜/人工膜・ダイナミクス,第46回日本生物物理学会年会)
- 我が国における Anaplasma phagocytophilum のp44/msp2相同性外被膜蛋白遺伝子群の解析
- ストレス負荷と食肉酵素分解物摂取による血清タンパク質の変動に関する研究
- Quantification of a Very Low Level of Serum Human Immunodeficiency Virus Type 1 (HIV-1) RNA Using Competitive PCR at Intervals and the Clinical Course
- Qualitative and Quantitative Detection of Cytomegalovirus DNA in Sera by PCR as a Clinical Marker
- Quantitative Detection of Human Immunodeficiency Virus Type 1 (HIV-1) RNA by PCR and Use as a Prognostic Marker and for Evaluating Antiretroviral Therapy
- Carbon dioxide emission derived from soil organic matter decomposition and root respiration in Japanese forests under different ecological conditions(Environment)
- Comparison of Different Soil Classification Systems Using 5 Profiles from Different Forest Ecosystems in Japan
- 多群飼育マウスの活動期における血中コルチコステロン濃度に及ぼすアニマルケアの影響
- Effects of St John's Wort extracts on corticosterone levels dysregulated by social isolation stress
- Temperature and moisture dependence of organic matter decomposition in soils from different environments, with special reference to the contribution of light- and heavy-fraction C
- 蛍光ディファレンスゲル二次元電気泳動(2D-DIGE)法を用いた細胞内寄生性新興感染症起因細菌の宿主応答解析
- Influence of the Galloyl Moiety in Tea Catechins on Binding Affinity for Human Serum Albumin
- Identification of Licocoumarone as an Apoptosis-Inducing Component in Licorice(Miscellaneous)
- Effects of fenofibrate on plasma and hepatic transaminase activities and hepatic transaminase gene expression in rats
- Social Stress Induces Oxidative DNA Damage in Mouse Peripheral Blood Cells
- Identification of Dimethylmatairesinol as an Immunoglobulin E-suppressing Component of the Leaves of Cinnamomum camphora
- Pro-Oxidant Action of Pyrroloquinoline Quinone : Characterization of Protein Oxidative Modifications
- Proteomic Identification of Serum Proteins Associated with Stress-Induced Gastric Ulcers in Fasted Rats
- Genistein Regulated Serotonergic Activity in the Hippocampus of Ovariectomized Rats under Forced Swimming Stress
- バイオMn酸化物へのCo(II), Ni(II),Zn(II)吸着に対する溶存酸素の影響
- Interaction of Tea Catechins with Lipid Bilayers Investigated by a Quartz-Crystal Microbalance Analysis
- Covalent Binding of Tea Catechins to Protein Thiols : The Relationship between Stability and Electrophilic Reactivity
- Human Serum Albumin as an Antioxidant in the Oxidation of (-)-Epigallocatechin Gallate : Participation of Reversible Covalent Binding for Interaction and Stabilization
- Evaluation of Superoxide Anion Radicals Generated from an Aqueous Extract of Particulate Phase Cigarette Smoke by Electron Spin Resonance Using 5,5-Dimethyl-1-pyrroline-N-oxide
- Effects of spaced feeding on gene expression of hepatic transaminase and gluconeogenic enzymes in rats
- Anthocyanins in Mesocarp/Epicarp and Endocarp of Fresh Acai (Euterpe oleracea Mart.) and their Antioxidant Activities and Bioavailability
- Detection of the New Ehrlichia Species Closely Related to Ehrlichia ewingii from Haemaphysalis longicornis in Yonaguni Island, Okinawa, Japan
- バイオマンガン酸化物と真菌混合系によるCo(II)の高効率な回収
- バイオマンガン酸化物の形成過程におけるMn(II)及びAs(V)の共吸着量の変化とその要因
- 夏季の浜名湖における緑色光合成硫黄細菌の分布と還元的リン溶出との関連
- Temperature and moisture dependence of organic matter decomposition in soils from different environments, with special reference to the contribution of light- and heavy-fraction C
- Comparison of Different Soil Classification Systems Using 5 Profiles from Different Forest Ecosystems in Japan
- Differences in micronucleus induction in peripheral blood reticulocytes of mice exposed to N-ethyl-N-nitrosourea at light and dark dosing times
- 4-Hydroxyestradiol Induces γ-H2AX in the Presence of an Inhibitor of Catechol-O-methyltransferase in Human Breast Cancer MCF-7 Cells
- Social isolation stress induces hepatic hypertrophy in C57BL/6J mice
- Organ-specific distribution of 7-chlorinated benz[a]anthracene and regulation of selected cytochrome P450 genes in rats
- Nocturnal Light Exposure Alters Hepatic Pai-1 Expression by Stimulating the Adrenal Pathwayin C3H Mice