多群飼育マウスの活動期における血中コルチコステロン濃度に及ぼすアニマルケアの影響
スポンサーリンク
概要
- 論文の詳細を見る
C57BL/6 mice were housed five per cage on a 12:12 h light/dark cycle. All animal care, including bed cleaning, was carried out during the nonactive phase. After 2 weeks, mean plasma corticosterone levels, collected during the nonactive (ZT6) and active (ZT18) phases, were 66.0 and 270.9 ng/ml, respectively. The values at ZT18 gradually increased in the order of the mice used for blood collection, but not at ZT6. When animal care was carried out at ZT18, the increasing pattern of plasma corticosterone levels previously observed at ZT18 was less pronounced after 2 weeks of acclimatization, and was not observed after 4 weeks. Therefore, animal care should be carried out in the active phase for at least 4 weeks before experiments involving stress responses in the active phase.
著者
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SHIMOI Kayoko
Graduate School of Nutritional and Environmental Sciences, University of Shizuoka
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SUZUKI Atsumi
Graduate School of Nutritional and Environmental Sciences, University of Shizuoka
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榊原 啓之
Graduate School of Nutritional and Environmental Sciences, University of Shizuoka
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小柳 顯陽
Graduate School of Nutritional and Environmental Sciences, University of Shizuoka
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鈴木 敬明
Shizuoka Industrial Research Institute
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LING Lin
Graduate School of Nutritional and Environmental Sciences, University of Shizuoka
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Suzuki Taka-aki
Shizuoka Industrial Research Institute
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Suzuki Atsumi
Graduate School Of Nutritional And Environmental Sciences Univ. Of Shizuoka
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Sakakibara Hiroyuki
Graduate School Of Nutritional And Environmental Sciences University Of Shizuoka
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Shimoi Kayoko
Graduate School Of Nutritional And Environmental Sciences And Global Coe Program University Of Shizu
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KOYANAGI Akiharu
Graduate School of Nutritional and Environmental Sciences, University of Shizuoka
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Sakakibara Hiroyuki
Graduate School Of Nutritional And Environmental Sciences And Global Coe Program University Of Shizu
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SHIMOI Kayoko
Graduate School of Integrated Pharmaceutical and Nutritional Sciences, University of Shizuoka
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