Identification of Dimethylmatairesinol as an Immunoglobulin E-suppressing Component of the Leaves of Cinnamomum camphora
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概要
- 論文の詳細を見る
Immunoglobulin E (IgE) plays an important role in allergic diseases. In this study, we found that a methanol extract of leaves of the camphor tree Cinnamomum camphora (C. camphora) reduced the amount of IgE secreted by human myeloma U266 cells. When the methanol extract was fractionated by extraction with organic solvents, the ethyl acetate fraction showed the highest activity. The fraction was further separated into several subfractions by preparative TLC. We identified the component of one of the active subfractions as dimethylmatairesinol. Authentic dimethylmatairesinol exhibited similar activity. Thus, the extract of C. camphora and its components including dimethylmatairesinol have potential as an anti-allergic agent.
著者
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安井 謙介
日清ファルマ株式会社 健康科学研究所
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Nakayama Tsutomu
Graduate School of Nutritional and Environmental Sciences and Global COE Program, University of Shiz
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Isemura Mamoru
Graduate School Of Nutritional And Environmental Sciences And Center Of Excellence For The 21^<st
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Nakayama Tsutomu
Graduate School Of Nutritional And Environmental Sciences And Global Coe Program Univ. Of Shizuoka
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Tanabe Hiroki
Graduate School of Nutritional and Environmental Sciences, University of Shizuoka
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Fukutomi Ryuuta
Nisshin Seifun Group Inc.
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Yasui Kensuke
Health Care Research Center, Nisshin Pharma Inc.
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Kaneko Akihiro
Health Care Research Center, Nisshin Pharma Inc.
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Imai Shinjiro
Nisshin Seifun Group Inc.
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安井 謙介
日新ファルマ株式会社健康科学研究所
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NAKAYAMA Tsutomu
Graduate School of Integrated Pharmaceutical and Nutritional Sciences, University of Shizuoka
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Nakayama Tsutomu
Graduate School of Nutritional and Environmental Sciences, University of Shizuoka
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Isemura Mamoru
Graduate School of Nutritional and Environmental Sciences, University of Shizuoka
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