Label-Free Ultrathin Pt Film Biosensor Using Phonon Vibrations Excited by Ultrafast Light Pulses
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概要
- 論文の詳細を見る
An ultrathin film oscillator biosensor is presented for highly sensitive monitoring of binding reactions among biomolecules in solutions. The phonon vibration along the thickness direction of an 18-nm Pt film is measured by ultrafast light pulses, whose fundamental resonance frequency is 120 GHz. The vibrational amplitude is monitored during binding reaction between human immunoglobulin G (hIgG) and anti-hIgG antibody, which exponentially decreases as the reaction progresses. A 6 pM hIgG solution can be detected. This biosensor also shows the ability to determine the affinity between proteins through the concentration dependence of the reaction rate.
- Japan Society of Applied Physicsの論文
- 2010-01-25
著者
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NAKAMURA Nobutomo
Graduate School of Engineering Science, Osaka University
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Ogi Hirotsugu
Graduate School Of Engineering Science Osaka University
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Hirao Masahiko
Graduate School Of Engineering Sci. Osaka Univ.
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Matsumoto Kozo
Graduate School Of Engineering Science Osaka University
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Fujita Yusaku
Graduate School of Engineering Science, Osaka University, Toyonaka, Osaka 560-8531, Japan
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Kawamoto Tetsuya
Graduate School of Engineering Science, Osaka University, Toyonaka, Osaka 560-8531, Japan
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Kawamoto Tetsuya
Graduate School Of Engineering Science Osaka University
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Nakamura Nobutomo
Graduate School Of Engineering Science Osaka University
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Fujita Yusaku
Graduate School Of Engineering Science Osaka University
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