High-Frequency Wireless and Electrodeless Quartz Crystal Microbalance Developed as Immunosensor
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概要
- 論文の詳細を見る
A wireless and electrodeless high-frequency quartz crystal microbalance (QCM) was developed for monitoring biochemical reactions in real time without using any labeling procedures. An analytical vibrational calculation for a multilayered plate showed that the QCM sensitivity significantly deteriorates when metallic electrodes are present on the crystal surfaces, indicating the importance of an electrodeless QCM biosensor. The 30-μm-thick electrodeless QCM immunosensor was excited, and its mechanical vibration was detected contactlessly using an antenna located outside the QCM cells. The homebuilt QCM system was used to detect human immunoglobulin G (hIgG) using staphylococcal protein A (SPA) immobilized on the crystal surface and to demonstrate the higher sensitivity of the electrodeless QCM than that of the conventional QCM. The 30-μm-thick QCM, with a 54 MHz fundamental frequency, successfully monitored the hIgG-SPA binding reaction for a hIgG concentration of 100 pg/mL.
- Published by the Japan Society of Applied Physics through the Institute of Pure and Applied Physicsの論文
- 2007-07-30
著者
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Nishiyama Masayoshi
Central Workshop Osaha University
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Ogi Hirotsugu
Graduate School Of Engineering Science Osaka University
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Hirao Masahiko
Graduate School Of Engineering Sci. Osaka Univ.
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Hatanaka Kenichi
Graduate School of Engineering Science, Osaka University, 1-3 Machikaneyama, Toyonaka, Osaka 560-8531, Japan
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Motohisa Kazuma
Graduate School of Engineering Science, Osaka University, 1-3 Machikaneyama, Toyonaka, Osaka 560-8531, Japan
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Ohmori Toshinobu
Graduate School of Engineering Science, Osaka University, 1-3 Machikaneyama, Toyonaka, Osaka 560-8531, Japan
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Nishiyama Masayoshi
Central Workshop, Osaka University, 1-2 Machikaneyama, Toyonaka, Osaka 560-8531, Japan
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