Detection of Glypican-3 Proteins for Hepatocellular Carcinoma Marker Using Wireless-Electrodeless Quartz-Crystal Microbalance
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概要
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Pure shear-wave resonances were excited and detected in 18- and 30-μm-thick electrodeless AT-cut quartz plates in liquids using line antennas contactlessly, achieving high-frequency quartz-crystal microbalances (QCMs). Their fundamental resonance frequencies (85 and 54 MHz) were monitored to study interactions in real time between human glypican-3 and an anti-glypican-3 antibody: glypican-3 is a prospective protein marker for hepatocellular carcinoma. Their affinity was determined by the Langmuir kinetics. This study demonstrates the high ability of the wireless-electrodeless QCM for detection of the protein markers and development of drugs for disorders.
- 2008-05-25
著者
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Ogi Hirotsugu
Graduate School Of Engineering Science Osaka University
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Hirao Masahiko
Graduate School Of Engineering Sci. Osaka Univ.
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Hatanaka Kenichi
Graduate School of Engineering Science, Osaka University, 1-3 Machikaneyama, Toyonaka, Osaka 560-8531, Japan
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Nishiyama Masayoshi
Renovation Center of Instruments for Science Education and Technology, Osaka University, 1-2 Machikaneyama, Toyonaka, Osaka 560-0043, Japan
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Omori Toshinobu
Graduate School of Engineering Science, Osaka University, 1-3 Machikaneyama, Toyonaka, Osaka 560-8531, Japan
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Nishiyama Masayoshi
Renovation Center of Instruments for Science Education and Technology, Osaka University, 1-2 Machikaneyama, Toyonaka, Osaka 560-8531, Japan
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