Expression of thymidine phosphorylase in choroidal malignant melanoma associated with neovascular glaucoma.
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概要
- 論文の詳細を見る
Reported herein is a case of 62-year-old man who complained of blurred vision and ocular pain in his right eye. The patient was diagnosed with choroidal melanoma complicated by neovascular glaucoma (NVG) and total retinal detachment, and he underwent enucleation of the eye. The isolated tumor was 2.5 × 2.5 cm in size. It was accompanied by intratumoral calcification, and consisted of epithelioid and spindle melanoma cells. There were a variety of microvessels in the stroma of the iris. The expression of thymidine phosphorylase (dThdPase), an angiogenic factor, was examined immunohistochemically. Cytoplasmic immunoreactivity for dThdPase was more prominent in the epithelioid cells than in spindle tumor cells. Another case of choroidal melanoma without NVG had less marked immunoreactivity. These results suggest that the production of dThdPase by melanoma cells correlates with the pathogenesis of NVG.
- Blackwell Publishing, Inc.の論文
- 2005-09-01
著者
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Yoshida Kazuhiko
Department of Medicine, Kidney Center, Tokyo Womens Medical University
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OHNO Shigeaki
Department of Ophthalmology and Visual Sciences, Hokkaido University Graduate School of Medicine
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ITO Hisao
Division of Organ Pathology, Department of Microbiology and Pathology, Department of Genetic Medicin
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Ohno Shigeaki
北海道大学 大学院医学研究科感覚器病学講座眼科学分野
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SHIRATORI Kenji
Department of Clinical Biochemistry, Tokyo University of Pharmacy and Life Science
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Shiratori Kenji
Department Of Clinical Biochemistry Tokyo University Of Pharmacy And Life Science
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SAITO WATARU
Department of Orthopaedic Surgery, Kitasato University, School of Medicine
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Saito Wataru
Department Of Ophthalmology And Visual Sciences Hokkaido University Graduate School Of Medicine
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NAMBA KENICHI
Department of Internal Medicine (3), Tokyo Medical & Dental University
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OSAKI Mitsuhiko
Division of Molecular Genetics and Biofunction, Department of Biomedical Science, Graduate School of
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Ito Hisao
Division Of Organ Pathology Department Of Microbiology And Pathology Faculty Of Medicine Tottori Uni
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Namba Kenichi
Department Of Ophthalmology And Visual Sciences Hokkaido University Graduate School Of Medicine
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KITAICHI Nobuyoshi
Department of Ophthalmology and Visual Science, Hokkaido University Graduate School of Medicine
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KASE Satoru
Department of Ophthalmology and Visual Sciences, Hokkaido University Graduate School of Medicine
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OHGAMI Kazuhiro
Department of Ophthalmology and Visual Sciences, Hokkaido University Graduate School of Medicine
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ADACHI Hironobu
Division of Organ Pathology, Department of Microbiology and Pathology, Tottori University, Faculty o
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Kase Satoru
Department Of Ophthalmology Hokkaido University Graduate School Of Medicine
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Ohno Shigeaki
Department Of Ocular Inflammation And Immunology Hokkaido University Graduate School Of Medicine
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Ohno Shigeaki
Department Of Ophthalmology And Visual Sciences Hokkaido University Graduate School Of Medicine
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Osaki Mitsuhiko
Division Of Molecular Genetics And Biofunction Department Of Biomedical Science Graduate School Of M
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Kitaichi Nobuyoshi
Department Of Ophthalmology Hokkaido University Graduate School Of Medicine
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Kitaichi Nobuyoshi
Department Of Ophthalmology And Visual Science Hokkaido University Graduate School Of Medicine
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Saito Wataru
Department Of Ophthalmology Hokkaido University Graduate School Of Medicine
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Namba Kenichi
Department Of Ophthalmology Hokkaido University Graduate School Of Medicine
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Ohno S
Department Of Ocular Inflammation And Immunology Hokkaido University Graduate School Of Medicine
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Saito Wataru
Department Of Electrical And Electronic Engineering Tokyo Institute Of Technology
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Kitaichi Nobuyoshi
Department Of Ophthalmology Health Sciences University Of Hokkaido
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Kase Satoru
Department Of Ophthalmology And Visual Sciences Hokkaido University Graduate School Of Medicine
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Ito Hisao
Division Of Organ Pathology Department Of Microbiology And Pathology
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Kaibara Nobuaki
Department Of Ophthalmology Hokkaido University Graduate School Of Medicine
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OHNO Shigeaki
Department of Ocular Inflammation and Immunology
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Yoshida Kazuhiko
Department of Chemistry, Faculty of Science and Technology, Sophia University
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