Evaluation of PTPN22 polymorphisms and Vogt-Koyanagi-Harada disease in Japanese patients

スポンサーリンク

概要

• 論文の詳細を見る

• Purpose: Vogt-Koyanagi-Harada (VKH) disease is an autoimmune disorder against melanocytes. Polymorphisms of the protein tyrosine phosphatase non-receptor 22 gene (PTPN22) have recently been reported to be associated with susceptibility to several autoimmune diseases. In this study, genetic susceptibility to VKH disease was investigated by screening for single nucleotide polymorphisms (SNPs) of PTPN22. Methods: A total of 167 Japanese patients with VKH disease and 188 healthy Japanese controls were genotyped by direct sequencing methods for six SNPs (rs3811021, rs1217413, rs1237682, rs3761935, rs3789608, and rs2243471) of PTPN22 including the uncoding exons. Results: The six SNPs in PTPN22 showed no significant association with susceptibility to VKH disease or its ocular, neurologic, or dermatological manifestation. Conclusions: Further studies are needed to clarify the genetic mechanisms underlying VKH disease.

• Molecular Visionの論文
• 2009-06-03

著者

• Morisaki Takayuki

  国立循環器病センター 心臓血管内科

• Kosakai Yoshio

  Department Of Cardiovascldar Surgery National Cardiovascudar Center

• Morisaki T

  Department Of Bioscience National Cardiovascular Center Research Institute

• Kadoshima Yoko

  Department Of Public Health Kanazawa Medical University

• Kaneko Yoshihiro

  The Second Department Of Internal Medicine Yokohama City University School Of Medicine

• Katsuyama Yoshihiko

  Department Of Hospital Pharmacy Shinshu University School Of Medicine

• Ohta Masaaki

  Department Of Pediatrics Ehime Prefecturel Imabari Hospital

• Ohno Shigeaki

  Department Of Ocular Inflammation And Immunology Hokkaido University Graduate School Of Medicine

• Ohno Shigeaki

  Department Of Ophthalmology And Visual Sciences Hokkaido University Graduate School Of Medicine

• Mizuki Nobuko

  Department Of Oral And Maxillofacial Surgery Yokohama City University Graduate School Of Medicine

• Kitaichi Nobuyoshi

  Department Of Ophthalmology Hokkaido University Graduate School Of Medicine

• Inoko Hidetoshi

  Dep. Of Molecular Life Sci. Tokai Univ. School Of Medicine

• Ota Masao

  Dep. Of Legal Medicine Shinshu Univ. School Of Medicine

• Mochizuki Naoki

  Research Institute National Cerebral And Cardiovascular Center

• Ohno S

  Department Of Ocular Inflammation And Immunology Hokkaido University Graduate School Of Medicine

• Kitaichi Nobuyoshi

  Department Of Ophthalmology Health Sciences University Of Hokkaido

• Horie Yukihiro

  Department Of Ophthalmology Hokkaido University Graduate School Of Medicine

• Kaibara Nobuaki

  Department Of Ophthalmology Hokkaido University Graduate School Of Medicine

• Miura Toshie

  Department Of Ophthalmology Hokkaido University Graduate School Of Medicine

• MIZUKI Nobuhisa

  Yokohama City University Graduate School of Medicine

関連論文

• Association of the Functional Variant in the 3-Hydroxy-3-Methylglutaryl-Coenzyme A Reductase Gene With Low-Density Lipoprotein-Cholesterol in Japanese
• Prevention of experimental autoimmune uveoretinitis by blockade of osteopontin with small interfering RNA
• サルベージ温熱化学療法が奏功した根治的化学放射線療法後再発食道癌の一例
• The Japanese Society of Hypertension Committee for Guidelines for the Management of Hypertension
• Risk of Smoking and Metabolic Syndrome for Incidence of Cardiovascular Disease : Comparison of Relative Contribution in Urban Japanese Population : The Suita Study
• Identification of Genetic Markers Associated With High-Density Lipoprotein-Cholesterol by Genome-Wide Screening in a Japanese Population : The Suita Study
• 日本人男性における飲酒とメタボリックシンドロームの疫学
• FRS-066 When and How should We Use Central BP in Clinical Hypertension? : Report from ABC-J Study(FRS14,New Aspects for Hypertension (H),Featured Research Session (English),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
• OE-145 Multi-center Cross-sectional Study to Characterize Antihypertensive Treatments in terms of Central Blood Pressure Evaluated by Radial Artery Pulse Waveform(Hypertension, clinical(01)(H),Oral Presentation(English),The 72nd Annual Scientific Meeting
• OE-071 A Genom-Wide Association Study of SNPs in the risk of Atherosclerosis Obliterans(Heart failure, clinical(01)(M),Oral Presentation(English),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
• FRS-007 Functional inhibition of p300 in the post-natal heart leads to mitochondrial dysfunction and cell death in mice(Novel Pathophysiological Mechanisms of Heart Failure(M),Featured Research Session,The 72nd Annual Scientific Meeting of the Japanese Ci
• ^I-IMP SPECTによる定量的脳血流測定 : dynamic収集データを用いた入力関数による新しい算出法
• OE-362 Genome-wide Search for Polymorphic Markers Associated with Lipid and Blood Pressure Levels in Japanese(OE61,Lipid Disorders (H),Oral Presentation (English),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
• 撓骨中の音波伝搬特性に関する検討
• Evaluation of the Effects of Shift Work on Nutrient Intake : A Cross-sectional Study
• Dietary Intake of Fatty Acids and Serum C-reactive Protein in Japanese
• PJ-104 Delayed Onset of Beating and Decreased Expression of T-type Ca^ Channel in Mouse ES Cell-Derived Cardiocytes Carrying Human Chromosome 21(Excitation-contraction coupling/Ion channel, The 71st Annual Scientific Meeting of the Japanese Circulatio
• Inhibition of Inward Rectifier K^+ Currents by Angiotensin II in Rat Atrial Myocytes : Lack of Effects in Cells from Spontaneously Hypertensive Rats
• 高分化型脂肪肉腫のMR画像と病理所見の相互関係
• -0282-DIRECT VISUALIZATION OF ENTRAINMENT BY EPICARDIAL ACTIVATION MAPPING DURING THE OPERATION
• Renoprotective Effect of Losartan in Comparison to Amlodipine in Patients with Chronic Kidney Disease and Hypertension-a Report of the Japanese Losartan Therapy Intended for the Global Renal Protection in Hypertensive Patients (JLIGHT) Study
• PJ-456 Role of Cysteinyl Leukotrienes in the Progression of Atherosclerosis in Mouse and in Human(PJ077,Infection/Inflammation/Immunity (H),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
• FRS-091 Impairment of Ubiquitin-Proteasome System Caused by a Missense MYBPC3 Mutation and Associated with Cardiac Dysfunction in Hypertrophic Cardiomyopathy(FRS19,Genetic Abnormalities in Cardiac Hypertrophy and Cardiomyopathy (M),Featured Research Sessi
• マルチスライスCTの画像データを用いたヒト腰椎インビボ3次元骨梁構造解析 : 横断的検討の第一報
• マルチスライスCTの画像データを用いたヒト腰椎インビボ3次元骨梁構造解析 : インビトロにおける再現性の検討
• Proctocolectomy for Colon Cancer Associated with Ulcerative Colitis a Few Months After Living Donor Liver Transplantation for Primary Sclerosing Cholangitis : Report of a Case
• 40歳代および60歳代男性の中等度飲酒の潜在性動脈硬化予防効果
• Variation in OSBPL10 is associated with dyslipidemia
• Association of Genetic Polymorphisms of Endothelin-Converting Enzyme-1 Gene with Hypertension in a Japanese Population and Rare Missense Mutation in Preproendothelin-1 in Japanese Hypertensives
• Evaluation of Emergency Coronary Artery Bypass Grafting within 2 Weeks of Acute Myocardial Infarction
• Coronary Artery Surgery in Patients with Aortitis Syndrome
• -0468-LATE RESULTS OF CORONARY BYPASS GRAFTINGS : THE RISK FACTORS ON CARDIAC EVENTS
• CRYOSURGERY FOR THE DRUG-RESISTANT VENTRICULAR TACHYCARDIA IN ARRHYTHMOGENIC RIGHT VENTRICULAR DYSPLASIA : APPROACH OF CRYOABLATION AND ITS LONG FOLLOW-UP RESULTS : Arrhythmias : 53 Annual Scientific Meeting, Japanese Circulation Society
• The KCNB1/E65K Polymorphism is Not Associated With Low Prevalence of Diastolic Blood Pressure in a Japanese Population
• Electrophysiologic Changes in Arrhythmogenic Substrate Following the Maze Procedure in Patients With Lone and Paroxysmal Atrial Fibrillation
• Percutaneous Transluminal Coronary Angioplasty and Coronary Artery Bypass Surgery : Early and follow-up clinical results : 54th Annual Scientific Session of the Japanese Circulation Society
• -0201-INCIDENCE AND THERAPY OF CORONARY ARTERY OBSTRUCTIVE DISEASE ASSOCIATED WITH ACQUIRED VALVULAR HEART DISEASE
• Problems and Anti-tachyarrhythmic Effects of Chronic Atrial Pacing : SYMPOSIUM ON INDICATION AND SELECTION OF ANTIARRHYTHMIC TREATMENT
• AN INTERPRETATION ABOUT INTERNODAL CONDUCTION FOR THE PREVENTION OF ARRHYTHMIAS FOLLOWING MUSTARD'S OPERATION : Surgical Block : PROCEEDINGS OF THE 44th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY
• EVALUATION OF LEFT VENTRICULAR FUNCTION AT ATRIAL AND VENTRICULAR PACING BY MULTI-GATED RADIONUCLIDE ANGIOGRAPHY : Nuclear Cardiology : PROCEEDINGS OF THE 44th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY
• INTERRELATIONSHIP AMONG EXTENT OF AKINETIC AREA OF LEFT VENTRICLE ANALYSED FROM BIPLANE CINE LVG AND LV-FUNCTION IN PTS. WITH MYOCARDIAL INFARCTION : Angioigraphy : PROCEEDINGS OF THE 44th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY
• -0679- Long term follow-up of arrhythmia, especially atrial fibrillation, after ASD radical operation(PROCEEDINGS OF THE 59th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY)
• Association of PLA2G7 polymorphisms with carotid atherosclerosis in hypertensive Japanese
• 一般地域住民にみるゲノム疫学研究への参加・不参加行動選択の理由
• PE-412 Triggering of AMI : The Ambient Temperature is Related to the Onset of AMI : Takashima AMI Registry(PE069,Preventive Medicine/Epidemiology/Education 2 (H),Poster Session (English),The 73rd Annual Scientific Meeting of the Japanese Circulation Socie
• OJ-011 Association of Obesity Related Factors with Plasma B-type Natriuretic Peptide Levels in General Japanese Population(OJ02,Obesity/SAS (H),Oral Presentation (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
• Genetic Variations of CYP2C9 in 724 Japanese Individuals and Their Impact on the Antihypertensive Effects of Losartan
• Leptin Gene and Leptin Receptor Gene Polymorphisms Are Associated with Sweet Preference and Obesity
• Associations of Hypertension and Its Complications with Variations in the Xanthine Dehydrogenase Gene
• 1 Role of the Ubiquitin Proteasome System in the Development of Heart Failure in Hypertrophic Cardiomyopathy(Young Investigator's Award for International Students Finalists Lecture (YIA International),Special Program,The 72nd Annual Scientific Meeting of
• PJ-180 Subtype Swithing of T-type Ca^ Channels from Cav3.2 to Cav3.1 during Differentiation of Embryonic Stem Cells to Cardiac Cell Lineage(Excitation-contraction coupling/Ion channel-2 (A) PJ30,Poster Session (Japanese),The 70th Anniversary Annual Sc
• Subtype Switching of T-Type Ca^ Channels From Cav3.2 to Cav3.1 During Differentiation of Embryonic Stem Cells to Cardiac Cell Lineage
• Identification of a novel insertion mutation in GATA3 with HDR syndrome
• Remote Reperfusion Lung Injury is Associated With AMP Deaminase 3 Activation and Attenuated by Inosine Monophosphate
• OE-193 Exaggeration of Remote Reperfusion Pulmonary Injury in AMP Deaminase 3 Knockout Mice(Metabolism/Biochemistry/Energetics-1 (H) OE33,Oral Presentation (English),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society)
• Genetic Polymorphisms of L-Type Calcium Channel α1c and α1D Subunit Genes are Associated With Sensitivity to the Antihypertensive Effects of L-Type Dihydropyridine Calcium-Channel Blockers
• PE-298 Feasibility of Undifferentiated ES Cell Engraftment to Diseased Hearts is Limited by Tumorigenesis and Apoptosis through Leukemia Inhibitory Factor (LIF)(Regeneration (angionenesis/myocardial regeneration)-5 (M) PE50,Poster Session (English),The 70
• Characterization of Subclinical Thyroid Dysfunction From Cardiovascular and Metabolic Viewpoints : The Suita Study
• Association of Sixty-One Non-Synonymous Polymorphisms in Forty-One Hypertension Candidate Genes with Blood Pressure Variation and Hypertension
• Polymorphisms in Vitamin K-Dependent γ-Carboxylation-Related Genes Influence Interindividual Variability in Plasma Protein C and Protein S Activities in the General Population
• Genetic Variations of HSD11B2 in Hypertensive Patients and in the General Population, Six Rare Missense/Frameshift Mutations
• OJ-041 A Common Genetic Variation in the ABCA1 Gene is Associated with Left Ventricular Diastolic Dysfunction in Men with Essential Hypertension(Atherosclerosis, clinical-3 (H) OJ7,Oral Presentation (Japanese),The 70th Anniversary Annual Scientific Meetin
• OE-045 Gene Polymorphisms of Circadian Rhythm Related Genes may be Contributed to Insulin Resistance in Patients with Hypertension(Hypertension, clinical-1 (H) OE8,Oral Presentation (English),The 70th Anniversary Annual Scientific Meeting of the Japanese
• OE-044 Polymorphisms of the Genes in Angiotensin II Signal Transduction May Influence the Antihypertensive Effect of Angiotensin II Receptor Blockers(Hypertension, clinical-1 (H) OE8,Oral Presentation (English),The 70th Anniversary Annual Scientific Meeti
• A Novel Missense Mutation, F826Y, in the Mineralocorticoid Receptor Gene in Japanese Hypertensives : Its Implications for Clinical Phenotypes
• Contribution of Single Nucleotide Polymorphisms in Protein-Tyrosin Kinase 2 to the Progression of Atherosclerosis in Patients with Essential Hypertension(Hypertension, Clinical 5 (H), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
• Association of Plasma Platelet Activating Factor-acetylhydrolase (PAF-AH) Gene Polymorphism with Carotid Atherosclerosis in Essential Hypertension(The Frontier of Atherosclerosis Research (IHD), The 69th Annual Scientific Meeting of the Japanese Circulati
• High-risk for Bradyarrhythmic Complications in Patients with Brugada Syndrome Caused by SCN5A Gene Mutations(Arrhythmia, Basic (A), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
• OE-217 Genetic Variation of Thrombomodulin Gene in Japanese Deep Vein Thrombosis Patients and in the General Population(Thromboembolism/Antithrombotic therapy/Thrombolysis-1 (H) OE37,Oral Presentation (English),The 70th Anniversary Annual Scientific Meeti
• PE-114 Angiotensin II Blocker, Valsartan, Supresses the Development of Experimental Abdominal Aortic Aneurysm in Rats(Peripheral circulation/Vascular disease(03)(H),Poster Session(English),The 72nd Annual Scientific Meeting of the Japanese Circulation Soc
• OJ-021 Blockade of T-type Calcium Channel Reduced the Arrythmogenicity in the Dominant Negative NRSF Transgenic Mice(Heart failure, basic-2 (M) OJ4,Oral Presentation (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Soc
• Pathophysiological Significance of T-type Ca^ Channels : Transcriptional Regulation of T-type Ca^ Channel : Regulation of CACNA1H by Neuron-Restrictive Silencer Factor
• Resistin Gene Polymorphism Positively Associated with the Metabolic Syndrome in Japanese Men(Gene Therapy/Genetic Engineering (IHD), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
• PJ-691 Inhibition of Development of Experimental Aortic Abdominal Aneurysm in Rat Model by Atorvastatin through Inhibition of Macrophage Migration(Peripheral circulation/Vascular disease-6, The 71st Annual Scientific Meeting of the Japanese Circulation So
• PE-543 Inhibiton of Experimental Aortic Abdominal Aneurysm by Angiotensin Receptor Blocker, Valsartan(Peripheral circulation/Vascular disease-4, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
• 4 Pharmacogenomic Approaches Targeted on the Tailor-made Medicine for Hypertension(Plenary Session 7 (PL-7) (M) Genomic Approaches to Cardiovascular Diseases : Present and Future,Special Program,The 72nd Annual Scientific Meeting of the Japanese Circulati
• Hypertension Susceptibility Genes on Chromosome 2p24-p25 in a General Japanese Population(Hypertension, Clinical 6 (H), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
• OJ-213 Prevention of Abdominal Aortic Aneurysm using Ribbon-type Chimeric Decoy Oligodeoxynucleotides against NF κ B and Ets in a Rat Model(Genetics/Genetically engineered models/Gene therapy-2(H/M), The 71st Annual Scientific Meeting of the Japanese Circ
• OJ-028 Role of NF κ B and Ets in Development of Abdominal Aortic Aneurysm in Human(Peripheral circulation/Vascular disease-2, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
• OJ-391 Hypertension Accelerated Experimental Abdominal Aortic Aneurysm through Up-regulation of Transcription Factors, NFkB and Ets(Peripheral circulation-2 (H) OJ66,Oral Presentation (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japane
• OJ-337 Regression of Abdominal Aortic Aneurysms by Chimeric Decoy Oligonucleotides against NF κ B and Ets Binding Sites in Rabbit Model(Genetics/Genetically engineered models/Gene therapy-1 (M) OJ57,Oral Presentation (Japanese),The 70th Anniversary Annual
• OJ-029 Suppression of Anastomotic Intimal Hyperplasia in Rabbit Hypercholesterolemic Model using Chimeric Decoy Oligodeoxynucleotides against NF κ B and E2F(Restenosis, basic/clinical-1 (IHD) OJ5,Oral Presentation (Japanese),The 70th Anniversary Annual Sc
• Regression of Experimental Rabbit Aortic Aneurysm by the Treatment with Chimeric Decoy Oligodeoxynucleotides (ODN) against Ets and NFkB(Gene Therapy 1 (IHD), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
• Inhibitory Effect of NFκB Decoy Oligodeoxynucleotides (ODN) on the Neointimal Hyperplasia in Rabbit Vein Graft Model(Cardiovascular Surgery/CABG 2 (IHD), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
• A Novel Approach to Treat Complete Atrio-ventricular (AV) Block by Transplantation of Embryonic Stem Cell-derived cardiac cells(Arrhythmia, Basic (A), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
• Genetic Risk Factors for Deep Vein Thrombosis among Japanese : Importance of Protein S K196E Mutation
• Evaluation of PTPN22 polymorphisms and Vogt-Koyanagi-Harada disease in Japanese patients
• Nano-Sized Carbon Black Exposure Exacerbates Atherosclerosis in LDL-Receptor Knockout Mice
• Transcriptional Regulation of the Pacemaker Channel HCN4 (Excitation-contraction Coupling/Ion Channel 2 (A), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
• PE-129 Exposure to Nano-Sized Carbon Black Accelerates Atherosclerosis in a Low Density Lipoprotein Receptor Knockout Mouse(Atherosclerosis, basic-7, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
• PJ-224 Genetic Contribution to Left Ventricular Diastolic Dysfunction in Essential Hypertension : Combined Effects of AT1, ETA, and MT1-MMP Gene Polymorphisms(Hypertension, clinical-9 (H) PJ38,Poster Session (Japanese),The 70th Anniversary Annual Scientif
• 5 Susceptible single nucleotide polymorphisms to the hypertensive complications and effectiveness of antihypertensive drugs(Perspectives of Genome-wide Study to Identify Genes Underlying Cardiovascular Diseases,Roundtable Discussion 10 (RT10) (M),The 70th
• Novel Genetic Polymorphisms of Orphan G-protein-coupled Receptors GPR91 and GPR99 Associated with Anti-atherosclerosis(Preventive Medicine/Epidemiology/Education/Health Policy 1 (H), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
• Pathophysiological Remodeling of Mouse Cardiac Myocytes Expressing Dominant Negative Mutant of Neuron Restrictive Silencing Factor
• Association of carotid atherosclerosis with genetic polymorphisms of the klotho gene in patients with hypertension
• Impact of RGS2 deficiency on the therapeutic effect of telmisartan in angiotensin II-induced aortic aneurysm
• Usefulness of antithrombin deficiency phenotypes for risk assessment of venous thromboembolism : type I deficiency as a strong risk factor for venous thromboembolism
• Evaluation of NLRP1 Gene Polymorphisms in Vogt-Koyanagi-Harada Disease
• The H-Invitational Database (H-InvDB), a comprehensive annotation resource for human genes and transcripts
• Hunting for genes for hypertension : the Millennium Genome Project for Hypertension

もっと見る 閉じる

スポンサーリンク