Pathophysiological Significance of T-type Ca^<2+> Channels : Transcriptional Regulation of T-type Ca^<2+> Channel : Regulation of CACNA1H by Neuron-Restrictive Silencer Factor

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概要

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• Expression of T-type Ca2+ current in the ventricle varies during development and in cardiac diseases. The alteration in quantity of two isoforms of T-type Ca2+ channel genes in the heart, CACNA1G and CACNA1H, contributes to the changes of T-type Ca2+ channel activity. However, the precise mechanisms governing the transcription of T-type Ca2+ channel genes remain largely unknown. In this review, we briefly describe our recent finding that a transcriptional repressor named neuron-restrictive silencer factor is a potent regulator of T-type Ca2+ channel gene expression.

• 社団法人 日本薬理学会の論文
• 2005-11-20

著者

• NAKAO Kazuwa

  Kyoto University

• Kaikita Koichi

  Department Of Cardiovascular Medicine Graduate School Of Medical Sciences Kumamoto University

• NAKAO Kazuwa

  Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine

• Kuwahara Koichiro

  Department Of Cardiovascular Medicine Graduate School Of Medical Sciences Kumamoto University

• Takano Makoto

  Division of Molecular Physiology and Biophysics, Department of Physiology, Jichi Medical University

• Nakao K

  Kyoto University

• Nakao Kazuwa

  大阪府立病院機構大阪府立急性期総合医療センター

• Nakao Kazuwa

  国立病院機構京都医療センター 代謝臨床研究センター内分泌研究部

• Morisaki Takayuki

  国立循環器病センター 心臓血管内科

• Kuwahara Koichiro

  京都大学 医学研究科内分泌代謝内科

• Kuwahara Koichiro

  Department Of Medicine And Clinical Science Kyoto University Graduate School Of Medicine

• Nakao Kazuwa

  奈良県立医科大学 内科学第一

• Nakao Kazuwa

  Department Of Endocrinology And Metabolism Kyoto University Graduate School Of Medicine

• Takano Makoto

  Division Of Biophysics Department Of Physiology Jichii Medical School

• Miyata Toshiyuki

  Department Of Preventive Cardiology National Cardiovascular Center:hygiene And Public Health Social

• Nakao Kazuwa

  The Department Of Medicine And Clinical Science

• Kuwahara Koichiro

  Department Of Medicine And Clinical Sciences Graduate School Of Medicine Kyoto University

• Nakao Kazuwa

  Department Of Endcrinology And Metabolism Kyoto University Graduate School Of Medicine

• Miyake Takashi

  Division Of Clinical Gene Therapy Osaka University Graduate School Of Medicine

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