Elevated Levels of Soluble Intercellular Adhesion Molecule-1 in the Coronary Circulation of Patients With Coronary Organic Stenosis and Spasm
スポンサーリンク
概要
- 論文の詳細を見る
The cell surface expression of intercellular adhesion molecule-1 (ICAM-1) is upregulated following activation during inflammatory responses, mediating both cell migration and activation. The involvement of inflammation in unstable angina is suggested by the presence of activated circulating leukocytes. To examine whether plasma soluble ICAM-1 (sICAM-1) levels increase in the coronary circulation of patients with coronary organic stenosis and coronary spasm, plasma sICAM-1 levels were measured in the coronary sinus(CS) and the aortic root(Ao) simultaneously in 10 patients with 90% or more coronary narrowing and coronary spasm (coronary spastic angina(CSA) with organic stenosis), in 11 patients with coronary spasm and no significant coronary narrowing (CSA without organic stenosis), in 16 patients with stable exertional angina, and in 13 control subjects. The plasma sICAM-1 levels (ng/ml) in the CS increased in CSA with organic stenosis (230±26) as compared with CSA without organic stenosis (158±14), stable exertional angina (130±9) and control subjects (121±10) (p<0.01). The levels in the Ao also increased in CSA with organic stenosis (208±24) as compared with CSA without organic stenosis (149±13), stable exertional angina (130±11) and control subjects (121±10) (p<0.01). Furthermore, the plasma sICAM-1 levels were higher in the CS than in the Ao only in CSA with organic stenosis. These results suggest that activation of leukocytes occurs through the induction of ICAM-1 in the coronary circulation in the patients with CSA with organic stenosis.
- 社団法人日本循環器学会の論文
- 2000-02-20
著者
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Ogawa Hisao
Department of Cardiology, Kumamoto University
-
Yoshimura Michihiro
Department of Caldiology Jikei University School of Medisine
-
Kaikita Koichi
Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University
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Sakamoto Tomohiro
Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University
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Kaikita Koichi
Department Of Cardiovascular Medicine Graduate School Of Medical Sciences Kumamoto University
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Soejima Hirofumi
Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University
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Yasue H
Kumamoto Univ. School Of Medicine
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MIYAMOTO Shinzo
Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University
-
Takazoe Keiji
Department of Cardiovascular Medicine, Kumamoto University School of Medicine
-
Nishiyama Koichi
Department Of Cardiovascular And Renal Medicine Saga University Faculty Of Medicine
-
Kugiyama Kiyotaka
Department of Internal Medicine II, University of Yamanashi
-
Yasue Hirofumi
Department Of Cardiovascular Medicine Graduate School Of Medical Sciences Kumamoto University
-
Takazoe Keiji
Division Of Cardiology Kumamoto Central Hospital
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Takazoe Keiji
Department Of Cardiovascular Center National Hospital Organization Kumamoto Medical Center
-
Nakao Koichi
Department Of Cardiology Saiseikai Kumamoto Hospital Cardiovascular Center
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Soejima Hirofumi
Department Of Cardiology Kumamoto Chuo Hospital
-
Miyamoto Shinzo
Department Of Cardiovascular Medicine Graduate School Of Medical Sciences Kumamoto University
-
Nishiyama Koichi
Department Of Biology
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Ogawa Hisao
Department Cardiovascular Medicine Kumamoto University:division Of Intensive Care Unit Kumamoto Univ
-
Yasue Hirofumi
Department Of Biology Institute For Medical Immunology Kumamoto University Medical School
-
Nakao Koichi
Division Of Cardiology Saiseikai Kumamoto Hospital
-
Kugiyama Kiyotaka
Department Of Internal Medicine Ii Interdisciplinary Graduate School Of Medicine And Engineering Uni
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Kugiyama Kiyotaka
The First Department Of Internal Medicine Kumamoto University Medical School
-
Kugiyama Kiyotaka
The Second Department Of Internal Medicine Interdisciplinary Graduate School Of Medicine And Enginee
-
Tanoue Kichi
Division Of Cardiology Kumamoto Central Hospital
-
Nishiyama Koichi
Department Of Physiological Chemistry And Etabolism Graduate School Of Medicine The University Of To
-
Node Koichi
Cardiovascular Center Saiseikai Kumamoto Hospital
-
Soejima Hirofumi
Department Of Cardiovascular Medicine Graduate School Of Medical Science Kumamoto University
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SAKAMOTO Tomohiro
Department of Cardiovascular Medicine, Graduate School of Medical Sciences Kumamoto University
-
Sakamoto Tomohiro
Department of Cardiology, Saiseikai Kumamoto Hospital, Japan
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