Tyrosinase gene family and Vogt-Koyanagi-Harada disease in Japanese patients.
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概要
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PURPOSE: The aim of the present study was to examine the genetic background of Vogt-Koyanagi-Harada (VKH) disease in a Japanese population by analyzing the tyrosinase gene family (TYR, TYRP1, and dopachrome tautomerase (DCT)). METHODS: 87 VKH patients and 122 healthy controls were genotyped using seven microsatellite markers on the candidate loci. We analyzed microsatellite (MS) polymorphisms at regions within tyrosinase gene family loci. In addition, the haplotype frequencies were also estimated and statistical analysis was performed. HLA-DRB1 genotyping was performed by the PCR-restriction fragment length polymorphism (RFLP) method. RESULTS: No significant evidence for an association was found. HLA-DRB1*0405 showed a highly significant association with VKH disease compared with the healthy controls (Pc=0.000000079), as expected. CONCLUSIONS: We concluded that there is no genetic susceptibility or increased risk attributed to the tyrosinase gene family. Our results suggest the need for further genetic study and encourage a search for novel genetic loci and predisposing genes in order to elucidate the genetic mechanisms underlying VKH disease.
- Molecular Visionの論文
- 2006-12-20
著者
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Ohta Masaaki
Department Of Pediatrics Ehime Prefecturel Imabari Hospital
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Namba Kenichi
Department Of Ophthalmology And Visual Sciences Hokkaido University Graduate School Of Medicine
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Kase Satoru
Department Of Ophthalmology Hokkaido University Graduate School Of Medicine
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Ohno Shigeaki
Department Of Ocular Inflammation And Immunology Hokkaido University Graduate School Of Medicine
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Ohno Shigeaki
Department Of Ophthalmology And Visual Sciences Hokkaido University Graduate School Of Medicine
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Mizuki Nobuko
Department Of Oral And Maxillofacial Surgery Yokohama City University Graduate School Of Medicine
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Inoko Hidetoshi
Dep. Of Molecular Life Sci. Tokai Univ. School Of Medicine
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Ota Masao
Dep. Of Legal Medicine Shinshu Univ. School Of Medicine
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Namba Kenichi
Department Of Ophthalmology Hokkaido University Graduate School Of Medicine
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Mochizuki Naoki
Research Institute National Cerebral And Cardiovascular Center
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Ohno S
Department Of Ocular Inflammation And Immunology Hokkaido University Graduate School Of Medicine
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Kase Satoru
Department Of Ophthalmology And Visual Sciences Hokkaido University Graduate School Of Medicine
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Horie Yukihiro
Department Of Ophthalmology Hokkaido University Graduate School Of Medicine
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MIZUKI Nobuhisa
Yokohama City University Graduate School of Medicine
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Hara Yuji
Department Of Epidemiology Research Institute National Cardiovascular Center
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