The electro-oculogram (EOG) in Vogt-Koyanagi-Harada's disease
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概要
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Purpose-To study the electro-oculogram (EOG) in Vogt-Koyanagi-Harada's (VKH) disease. Methods-We measured the EOG and examined the influence of the extent of retinal detachment (RD) on the RPE in eight patients with VKH disease. The EOG was measured three times in each patient: before, one month after, and one year after systemic corticosteroid therapy. The ratio of light peak to dark trough (L/D ratio) was calculated. The EOG was also measured in normal controls. Results-The L/D ratio in VKH disease was 1.60 ± 0.25 before therapy, which was a significant (p< 0. 01) reduction compared with that in normal controls (2.04 ± 0.23). The L/D ratio in VKH patients with inextentsive RD (1.63) returned to the level of normal controls one year after therapy (2.02). On the other hand, the L/D ratio in the patients with extensive RD (1.55) was further reduced (1.32) one month after therapy and showed no return. Conclusion-EOG was severely and irreversibly damaged in case of VKH patients with extensive RD. Therefore the steroid pulse therapy has an adequacy in the treatment of those cases to suppress the inflammation and damage of RPE.
- 横浜市立大学の論文
- 2005-03-31
著者
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NAKAMURA Satoshi
Department of Neurosurgery, Tokyo Women's Medical University
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OHNO Shigeaki
Department of Ophthalmology and Visual Sciences, Hokkaido University Graduate School of Medicine
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SUGITA Miyuki
Department of Ophthalmology, Yokohama City University School of Medicine
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Ohno Shigeaki
Department Of Ophthalmology Yokohama City University School Of Medicine
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Sugita Miyuki
Department Of Ophthalmology Yokohama City University School Of Medicine
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Ohno Shigeaki
Department Of Ocular Inflammation And Immunology Hokkaido University Graduate School Of Medicine
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Shimonaka Keiko
Department of Ophthalmology, Yokohama City University School of Medicine
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Shimonaka Keiko
Department Of Ophthalmology Yokohama City University School Of Medicine
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Nakamura Satoshi
Department Of Botany Graduate School Of Science Kyoto University
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Nakamura Satoshi
Department Of Bioengineering Tokyo Institute Of Technology
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Nakamura Satoshi
Department Of Acoustic And Speech Research Advance Telecommunications Research Institute International
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NAKAMURA Satoshi
Department of Ophthalmology, Yokohama City University School of Medicine
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OHNO Shigeaki
Department of Ocular Inflammation and Immunology
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NAKAMURA SATOSHI
Department o Biophysics and Biochemistry, Faculty of Science, University of Tokyo
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