Replication of a microsatellite genome-wide association study of Behçet's disease in a Korean population
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概要
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Objective: Behcet disease is one of the major etiologies of uveitis causing blindness in Asian countries. A genome-wide association study identified 6 microsatellite markers as disease susceptibility loci for Japanese patients with Behcet disease. To confirm our recent results, these microsatellite markers were examined in a Korean population as a replication study. Methods: Study participants included 119 Behcet patients and 141 controls. All were enrolled in Korea. Association between the 6 reported microsatellite markers (D3S0186i, D6S0014i, D6S0032i, 536G12A, D12S0645i, and D22S0104i) and Behcet disease was analysed. HLA-B was genotyped by sequence-based typing methods. Results: A microsatellite marker located near the HLA-B region demonstrated significant association with Behcet disease (P = 0.028). The genotype and phenotype frequencies of the HLA-B*51 gene were significantly increased in patients (23.1% and 39.5%, respectively) compared with healthy controls (11.2% and 20.1%, respectively; P < 0.001). Conclusions: Microsatellite analysis revealed that the HLA-B*51 gene was strongly associated with Behcet disease in a Korean population.
著者
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Meguro Akira
Department Of Ophthalmology And Visual Science Yokohama City University Graduate School Of Medicine
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Ohta Masaaki
Department Of Pediatrics Ehime Prefecturel Imabari Hospital
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Namba Kenichi
Department Of Ophthalmology And Visual Sciences Hokkaido University Graduate School Of Medicine
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Ohno Shigeaki
Department Of Ophthalmology And Visual Sciences Hokkaido University Graduate School Of Medicine
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Mizuki Nobuko
Department Of Oral And Maxillofacial Surgery Yokohama City University Graduate School Of Medicine
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Noda Kousuke
Department Of Ophthalmology Hokkaido University Graduate School Of Medicine
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Inoko Hidetoshi
Dep. Of Molecular Life Sci. Tokai Univ. School Of Medicine
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Ota Masao
Dep. Of Legal Medicine Shinshu Univ. School Of Medicine
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Mochizuki Naoki
Research Institute National Cerebral And Cardiovascular Center
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Ohno S
Department Of Ocular Inflammation And Immunology Hokkaido University Graduate School Of Medicine
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Kitaichi Nobuyoshi
Department Of Ophthalmology Health Sciences University Of Hokkaido
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Horie Yukihiro
Department Of Ophthalmology Hokkaido University Graduate School Of Medicine
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Kaibara Nobuaki
Department Of Ophthalmology Hokkaido University Graduate School Of Medicine
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MIZUKI Nobuhisa
Yokohama City University Graduate School of Medicine
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