Antiproliferative Activity of Root Extract from Gentian Plant (Gentiana triflora) on Cultured and Implanted Tumor Cells

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概要

• 論文の詳細を見る

• We describe a novel pharmacological activity of the gentian root, an ingredient of Chinese medicines. Root extract from Gentiana triflora triggered cell death of human Daudi cells in culture. In addition, daily administration of the extract to mice inhibited growth of implanted solid tumors. Extract treatment of cultured cells resulted in the appearance of shranken, fragmented, or condensed cell and nuclear morphologies, and in chromosomal DNA degradation. But, the extract-treated cells did not show DNA fragmentation, which exhibits a nucleosome ladder, suggesting that extract-triggered cell death is not mediated through a typical apoptotic pathway.

• 社団法人 日本農芸化学会の論文
• 2006-04-23

著者

• Yamashita Tetsuro

  Department Of Chemical Engineering Faculty Of Engineering Iwate University

• FUJIOKA Tomoaki

  Department of Urology, Iwate Medical University

• Fujioka Tomoaki

  Department Of Urology Iwate Medical University School Of Medicine

• Saitoh Yasushi

  United Graduate School Of Agricultural Sciences Iwate Univ.

• Hikage Takashi

  Cryobiosystem Research Center Iwate University

• MATSUKAWA Kazushige

  Cryobiosystem Research Center, Iwate University

• OGATA Mika

  Cryobiosystem Research Center, Iwate University

• MINAMI Hiroyuki

  Cryobiosystem Research Center, Iwate University

• SHIMOTAI Yoshitaka

  Cryobiosystem Research Center, Iwate University

• SAITOH Yasushi

  Cryobiosystem Research Center, Iwate University

• OUCHI Atsushi

  Department of Urology, Iwate Medical University School of Medicine

• TSUTSUMI Reiko

  Department of Virology, Iwate Medical University School of Medicine

• TSUTSUMI Ken-ichi

  Cryobiosystem Research Center, Iwate University

• Yamashita Tetsuro

  Department Of Agro-bioscience Faculty Of Agriculture Iwate University

• Minami Hiroyuki

  Cryobiosystem Research Center Iwate University

• Ogata Mika

  Cryobiosystem Research Center Iwate University

• Tsutsumi Ken-ichi

  United Graduate School Of Agricultural Sciences Iwate Univ.

• Tsutsumi Ken-ichi

  Cryobiosystem Research Center Iwate University

• Ouchi Atsushi

  Department Of Radiology Sapporo Medical University School Of Medicine

• Ouchi Atsushi

  Department Of Urology Iwate Medical University School Of Medicine

• Saitoh Yasushi

  Cryobiosystem Research Center Iwate University

• Tsutsumi Reiko

  Department Of Virology Iwate Medical University School Of Medicine

• Tsutsumi Reiko

  Department Of Bacteriology Iwate Medical University

• Fujioka Tomoaki

  Department Of Urology And Physiology Ii Iwate Medical University School Of Medicine

• Matsukawa Kazushige

  Cryobiosystem Research Center Iwate University

• Shimotai Yoshitaka

  Cryobiosystem Research Center Iwate University

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