MELAS and Reversible Vasoconstriction of the Major Cerebral Arteries
スポンサーリンク
概要
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A 26-year-old woman was admitted due to an altered mental status and generalized tonic-clonic seizures. She had experienced chronic migraine-like headaches, progressive bilateral hearing loss, a short stature and nephrotic syndrome. Laboratory data showed elevated lactate and pyruvate levels. Brain MRI using diffusion-weighted imaging revealed a hyperintense lesion in the left temporal lobe. MR angiography revealed segmental stenosis at the C1 and M1-2 junction. A genetic study revealed a mitochondrial DNA A3243G point mutation. The patient's clinical symptoms and MRI/MR angiography (MRA) findings improved within four weeks. We herein discuss the possible pathophysiology involving both stroke-like episodes and reversible vasoconstriction.
著者
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Ouchi Atsushi
Department Of Radiology Sapporo Medical University School Of Medicine
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Miura Daisuke
Department of Applied Physics, Tohoku University, Sendai 980-8579, Japan
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Yoshida Takeshi
Department of Applied Physics, Graduate School of Engineering, Osaka University, Suita, Osaka 565-0871, Japan
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Miura Daisuke
Department of Internal Medicine, Okinawa Hokubu Hospital, Japan
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Shimoji Kunihiro
Department of Internal Medicine, Okinawa Hokubu Hospital, Japan
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Kinjo Kazushi
Department of Internal Medicine, Okinawa Hokubu Hospital, Japan
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Sueyoshi Takeshi
Department of Radiology, Okinawa Chubu Hospital, Japan
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Jonosono Manabu
Department of Neurology, Okinawa Chubu Hospital, Japan
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Rajput Vijay
Department of Medical Education, Cooper Medical School of Rowan University, USA
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Yoshida Takeshi
Department of Neurology, Okinawa Chubu Hospital, Japan
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