Effects of the Principal Nutrients on Lovastatin Production by Monascus pilosus
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概要
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Lovastatin production is dependent on the substrates provided. We investigated how several carbon and nitrogen sources in the medium affect lovastatin production by Monascus pilosus. M. pilosus required a suitable concentration of organic nitrogen peptone for high lovastatin production. As sole carbon source with peptone, although glucose strongly repressed lovastatin production, maltose was responsible for high production. Interestingly, glycerol combined with maltose enhanced lovastatin production, up to 444 mg/l in the most effective case. Moreover, an isolated mutant, in which glucose repression might be relieved, easily produced the highest level of lovastatin, 725 mg/l on glucose–glycerol–peptone medium. These observations indicate that lovastatin production by M. pilosus is regulated by strict glucose repression and that an appropriate release from this repression by optimizing medium composition and/or by a mutation(s) is required for high lovastatin production.
- 社団法人 日本農芸化学会の論文
- 2006-05-23
著者
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Inagaki Kenji
Department of Bioresources Chemistry, Graduate School of Natural Science and Technology, Okayama Uni
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Inagaki Kenji
Department Of Biofunctional Chemistry Graduate School Of Natural Science And Technology Okayama Univ
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Zhang Ming-yong
Industrial Technology Center Of Okayama Prefecture
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MIYAKE Tsuyoshi
Industrial Technology Center of Okayama Prefecture
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KONO Isato
Industrial Technology Center of Okayama Prefecture
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NOZAKI Nobuyuki
Industrial Technology Center of Okayama Prefecture
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SAMMOTO Hiroyuki
Industrial Technology Center of Okayama Prefecture
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UCHITOMI Kumiko
Department of Biofunctional Chemistry, Graduate School of Natural Science and Technology, Okayama Un
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Uchitomi Kumiko
Department Of Biofunctional Chemistry Graduate School Of Natural Science And Technology Okayama Univ
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Inagaki Kenji
Dep. Of Bioresources Chemistry Graduate School Of Natural Sci. And Technol. Okayama Univ.
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