Cloning and Characterization of a cDNA Encoding the Histone Acetyltransferase Monocytic Leukemia Zinc Finger Protein (MOZ) in the Rat
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概要
- 論文の詳細を見る
Many DNA-binding transcription factors require coactivators for their function. Some of these coactivators have histone acetyltransferase (HAT) activity, which is important for transcription from chromatin template. We cloned a cDNA encoding the rat homolog of monocytic leukemia zinc finger protein (MOZ), a member of the MYST (MOZ, Ybf2/Sas3, Sas2, and Tip60) acetyltransferase family. Rat MOZ (rnMOZ) encoded 1998 amino acids and was composed of 16 exons. Comparison of the rnMOZ and human MOZ amino acid sequences revealed 89% identity over the whole sequence and 100% identity in the MYST region, which is essential for HAT activity. Further, we identified physical interaction between rnMOZ and basic leucine zipper (bZIP)-type DNA-binding proteins, including c-Jun and CCAAT/enhancer binding proteins. This finding suggests that MOZ may function in multiple cellular processes through various bZIP-type transcription factors.
- 社団法人日本薬学会の論文
- 2005-04-01
著者
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OSADA Shigehiro
Department of Molecular Biology, Graduate School of Pharmaceutical Sciences, Nagoya City University
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Nishikawa Jun-ichi
大阪大学 薬学研究科生命情報環境科学
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Nishikawa J
Laboratory Of Environmental Biochemistry Graduate School Of Pharmaceutical Sciences Osaka University
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NISHIHARA Tsutomu
Laboratory of Environmental Biochemistry, Graduate School of Pharmaceutical Sciences Osaka Universit
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Nishikawa Jun-ichi
Laboratory Of Environmental Biochemistry Graduate School Of Pharmaceutical Sciences Osaka University
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Ohta Kumiko
Laboratory of Environmental Biochemistry, Graduate School of Pharmaceutical Sciences, Osaka Universi
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Osada Shigehiro
Laboratory of Environmental Biochemistry, Graduate School of Pharmaceutical Sciences, Osaka Universi
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Nishikawa Junichi
Laboratory of Environmental Biochemistry, Graduate School of Pharmaceutical Sciences, Osaka Universi
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Ohta Kumiko
Laboratory Of Environmental Biochemistry Graduate School Of Pharmaceutical Sciences Osaka University
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Osada Shigehiro
Department Of Molecular Biology Graduate School Of Pharmaceutical Sciences Nagoya City University
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Nishihara Tsutomu
Laboratory Of Environmental Biochemistry Graduate School Of Pharmaceutical Sciences Osaka University
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Nishihara Tsutomu
Laboratory Of Environmental Biochemistry Graduate School Of Pharmaceutical Sciences Osaka University
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Nishikawa Junichi
Laboratory Of Biochemistry Faculty Of Pharmaceutical Sciences Osaka University
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