Methoxychlor Induces CYP2C11 to Convert Itself into Hormonally Active Metabolites
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概要
- 論文の詳細を見る
Methoxychlor(MXC), a chlorinated hydrocarbon pesticide, adversely affects the hormonal system in animals by producing metabolites with estrogenic activity. When methoxychlor was administrated to male rats for 7 days, CYP2C11 as well as its 2B1/2 and 3A1 was induced in the liver. In addition, an in vitro study using recombinant CYPs and HPLC analysis showed that only the CYP2C11 subfamily converted MXC into hormonally active metabolites, such as demethylated derivatives, not 2B1 and 3A1. These findings suggest that MXC accelerates the conversion of itself into hormonally active metabolites, leading to disruption of the endocrine system.
- 公益社団法人日本薬学会の論文
- 2003-06-01
著者
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Harada Shingo
Laboratory Of Environmental Biochemistry Graduate School Of Pharmaceutical Sciences Osaka University
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NISHIHARA Tsutomu
Laboratory of Environmental Biochemistry, Graduate School of Pharmaceutical Sciences Osaka Universit
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Nishikawa Jun-ichi
Laboratory Of Environmental Biochemistry Graduate School Of Pharmaceutical Sciences Osaka University
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Mikamo Eriko
Laboratory of Environmental Biochemistry, Graduate School of Pharmaceutical Sciences, Osaka Universi
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Mikamo Eriko
Laboratory Of Environmental Biochemistry Graduate School Of Pharmaceutical Sciences Osaka University
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Nishihara Tsutomu
Laboratory Of Environmental Biochemistry Graduate School Of Pharmaceutical Sciences Osaka University
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