Anti-Androgenic Activity of N-Nitrosodibenzylamine, N-Nitrosodiphenylamine and N-Nitrosodicyclohexylamine
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概要
- 論文の詳細を見る
When 56 selected environmental chemicals were tested for the androgenic activity to Yeast Two-hybrid and reporter gene assay in the presence of 5α-dihydrotestosterone (DHT), the activity was inhibited by some of the chemicals including N-nitrosodiphenylamine (NDPA), a novel anti-androgenic compound, and one of suspected carcinogenic N-nitrosocompounds (NOCs) commonly used as material of rubber and plastic goods. We further examined 15 NOCs for anti-androgenic activity, and found that N-nitrosodibenzylamine (NDBzA) and N-nitrosodicyclohexylamine (NDCHA) as well as NDPA inhibited the activity of DHT in a dose-dependent manner. These compounds showed the competitive binding to androgen receptor (AR) against DHT and decreased the level of AR protein. Furthermore, 3 NOCs down-regulated the prostate specific antigen (PSA) at the transcriptional level in LNCaP cells. These results suggest that some NOCs antagonized the androgenic effect of DHT in the same manner as the synthetic anti-androgen, flutamide (F).
- 公益社団法人日本薬学会の論文
- 2006-10-01
著者
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Nishikawa Jun-ichi
大阪大学 薬学研究科生命情報環境科学
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Nishikawa J
Laboratory Of Environmental Biochemistry Graduate School Of Pharmaceutical Sciences Osaka University
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Iida Mitsuru
Edc Analysis Center Otsuka Pharmaceutical Company Ltd.
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NISHIHARA Tsutomu
Laboratory of Environmental Biochemistry, Graduate School of Pharmaceutical Sciences Osaka Universit
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Nishikawa Jun-ichi
Laboratory Of Environmental Biochemistry Graduate School Of Pharmaceutical Sciences Osaka University
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HORIGUCHI Kikumi
Laboratory of Environmental Biochemistry, Graduate School of Pharmaceutical Sciences, Osaka Universi
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Nishinaka T
Osaka Univ. Pharmaceutical Sci. Osaka Jpn
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Hari Sayaka
Laboratory of Environmental Biochemistry, Graduate School of Pharmaceutical Sciences, Osaka Universi
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Nishihara T
Department Of Oral Microbiology Kyushu Dental College
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Nishihara Tsutomu
Laboratory Of Environmental Biochemistry Graduate School Of Pharmaceutical Sciences Osaka University
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Hari Sayaka
Laboratory Of Environmental Biochemistry Graduate School Of Pharmaceutical Sciences Osaka University
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Nishihara Tsutomu
Laboratory Of Environmental Biochemistry Graduate School Of Pharmaceutical Sciences Osaka University
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Nishihara T
Fac. Of Pharmaceutical Sciences Hyogo Univ. Of Health Sciences
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Nishihata Tomohiro
Institute Of Natural Medicine University Of Toyama
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Horiguchi Kikumi
Laboratory Of Environmental Biochemistry Graduate School Of Pharmaceutical Sciences Osaka University
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