Interactions of Thyroid Hormone Receptor with Ku Proteins and Interleukin Enhancer Binding Factor 3 Modulate the Promoter Activity of Thyroid-Stimulating Hormone Alpha
スポンサーリンク
概要
- 論文の詳細を見る
We previously identified Ku proteins and interleukin enhancer binding factor 3 (ILF3) as cofactors for the nuclear receptor farnesoid X receptor and liver receptor homolog-1, respectively. Here we provide further evidence that these cofactors modulate the promoter activity of the nuclear receptor thyroid hormone receptor (TR) target gene, thyroid-stimulating hormone alpha (TSHα), which is negatively regulated by the TR ligand triiodothyronine (T3). Ku proteins suppressed TSHα promoter activity independent of T3, whereas ILF3 enhanced TSHα activity, especially in the presence of T3. Taken together, our results suggest that Ku proteins and ILF3 function as co-regulators for TR-mediated TSHα expression.
著者
-
OSADA Shigehiro
Department of Molecular Biology, Graduate School of Pharmaceutical Sciences, Nagoya City University
-
Osada Shigehiro
Department Of Molecular Biology Graduate School Of Pharmaceutical Sciences Nagoya City University
-
Nishizuka Makoto
Department Of Molecular Biology Graduate School Of Pharmaceutical Sciences Nagoya City University
-
Imagawa Masayoshi
Department Of Environmental Biochemistry Faculty Of Pharmaceutical Sciences Osaka University
-
Ohno Masae
Department of Molecular Biology, Graduate School of Pharmaceutical Sciences, Nagoya City University
-
Fujita Mayu
Department of Molecular Biology, Graduate School of Pharmaceutical Sciences, Nagoya City University
-
Osada Shigehiro
Department of Environmental Biochemistry, Faculty of Pharmaceutical Sciences, Osaka University
関連論文
- Toxicity of Nickel Compounds Mediated by HTZ1, Histone Variant H2A.Z, in Saccharomyces cerevisiae(Molecular and Cell Biology)
- TC10-Like/TC10βLong Regulates Adipogenesis by Controlling Mitotic Clonal Expansion
- Gelsolin, an Actin Regulatory Protein, is Required for Differentiation of Mouse 3T3-L1 Cells into Adipocytes
- Promotion of Anchorage-independent Growth by Cytoplasmic and Nuclear Histone Deacetylase 9
- His151 and His296 Are the Acid-Base Catalytic Residues of Bacillus cereus Sphingomyelinase in Sphingomyelin Hydrolysis
- Cloning and Characterization of a cDNA Encoding the Histone Acetyltransferase Monocytic Leukemia Zinc Finger Protein (MOZ) in the Rat
- 1-Chloro-2,4-Dinitrobenzene Stimulates the Estrogenic Activity in MCF-7 Cells
- Specific Detection of Lysophosphatidic Acids in Serum Extracts by Tandem Mass Spectrometry
- Repression of the Promoter Activity Mediated by Liver Receptor Homolog-1 through Interaction with Ku Proteins
- Fad24 Causes Hyperplasia in Adipose Tissue and Improves Glucose Metabolism
- Identification of a Novel Vitamin D Response Element from the Rat Genome^1
- FAD24, a Regulator of Adipogenesis, is Required for the Regulation of DNA Replication in Cell Proliferation(Molecular and Cell Biology)
- Isolation of Genes Regulated by Peroxisome Proliferator-Activated Receptor γ(PPARγ) by Two-Dimensional Electrophoresis and Mass Spectrometry
- Development of Standardized in Vitro Assay System for Estrogen Receptors and Species Specificity of Binding Ability of 4-Nonylphenol and p-Octylphenol
- Development of a Competitive Enzyme Immunoassay for Detection of Capacity of Chemicals to Bind Quail Estrogen Receptor α and β
- Glu-53 of Bacillus cereus Sphingomyelinase Acts as an Indispensable Ligand of Mg^ Essential for Catalytic Activity
- Nuclear Factor 1 Family Proteins Bind to the Silencer Element in the Rat Glutathione Transferase P Gene^1
- Histone Methyltransferase PR-Set7 and Histone Variant H2A.Z, Induced during Hepatocarcinogenesis, Repress the Promoter Activity of the Tumor Marker Gene and the Ras-Induced Colony Formation Activity
- Functional Analysis of Zinc Finger Proteins That Bind to the Silencer Element in the Glutathione Transferase P Gene
- Identification of Zinc Finger Proteins Bound to a Silencer Region in the Rat Glutathione Transferase P Gene
- Gene Expression of CCAAT/Enhancer-Binding Protein δ Mediated by Autoregulation Is Repressed by Related Gene Family Proteins
- Genomic Organization of the Rat Nuclear Factor I-A Gene
- CCAAT/Enhancer-Binding Protein δ Gene Expression Is Mediated by APRF/STAT3^1
- Factor for Adipocyte Differentiation 158 Gene Disruption Prevents the Body Weight Gain and Insulin Resistance Induced by a High-Fat Diet
- Evaluation of Ability of Chemicals to Bind Frog (Xenopus laevis) Estrogen Receptor by in Vitro Binding Assay
- Effective Extraction and Analysis for Lysophosphatidic Acids and Their Precursors in Human Plasma Using Electrospray Ionization Mass Spectrometry
- Interactions of Thyroid Hormone Receptor with Ku Proteins and Interleukin Enhancer Binding Factor 3 Modulate the Promoter Activity of Thyroid-Stimulating Hormone Alpha