Biological Evaluation of 2-Aryl-2-fluoropropionic Acids as Possible Platforms for New Medicinal Agents

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概要

• 論文の詳細を見る

• We investigated the cyclooxygenase (COX) inhibitory and anticancer activities of 2-aryl-2-fluoropropionic acids 1a-e. These fluorinated compounds showed lower inhibitory activity toward COX-1 than the corresponding non-fluorinated compounds 2a-e with retained inhibitory activity against COX-2 resulting in modification of the balance of COX-1/COX-2 inhibitions, and they showed little anticancer activity. Interesting differences of the activities between (S)- and (R)-enantiomers were observed in some cases.

• 社団法人日本薬学会の論文
• 2005-08-01

著者

• 竹内 義雄

  富山大院医薬

• TAKEUCHI Yoshio

  Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University

• FUJISAWA Hidehito

  Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University

• FUJIWARA Tomoya

  Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University

• MATSUURA Mamoru

  Pharmaceuticals Research Unit, Research & Development Division, Mitsubishi Pharma Corporation

• KOMATSU Hirotsugu

  Pharmaceuticals Research Unit, Research & Development Division, Mitsubishi Pharma Corporation

• UENO Satoshi

  Yakult Central Institute for Microbiological Research

• MATSUZAKI Takeshi

  Yakult Central Institute for Microbiological Research

• Matsuura Mamoru

  Pharmaceuticals Research Unit Research & Development Division Mitsubishi Pharma Corporation

• Fujiwara Tomoya

  Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceutical University

• Fujisawa Hidehito

  Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceutical University

• Komatsu Hirotsugu

  Pharmaceuticals Research Division Mitsubishi Pharma Corporation

• Komatsu Hirotsugu

  Pharmaceuticals Research Unit Research & Development Division Mitsubishi Pharma Corporation

• Takeuchi Yoshio

  Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceutical University

• Matsuzaki Takeshi

  Yakult Central Inst. For Microbiological Res.

• Takeuchi Yoshio

  Faculty Of Pharmaceutical Sciences Toyama Medical & Pharmaceutical University

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