Synthesis and Optical Resolution of 2-Aryl-2-fluoropropionic Acids, Fluorinated Analogues of Non-steroidal Anti-inflammatory Drugs (NSAIDs)

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概要

• 論文の詳細を見る

• We report the synthesis of optically active 2-aryl-2-fluoropropionic acids 2 as non-epimerizable mimics of 2-arylpropionic acids 1, a class of compounds which have been widely used as non-steroidal anti-inflammatory drugs (NSAIDs). This is a continuation of our research involving the design, synthesis, and evaluation of chiral fluorine-containing organic molecules as effective analogues of pharmacologically important compounds.

• 社団法人日本薬学会の論文
• 2005-05-01

著者

• 竹内 義雄

  富山大院医薬

• TAKEUCHI Yoshio

  Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University

• FUJISAWA Hidehito

  Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University

• FUJIWARA Tomoya

  Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University

• OMATA Kenji

  Department of Chemistry, Graduate School of Science, Tohoku University

• Omata Kenji

  Department Of Chemistry Graduate School Of Science Tohoku University

• Omata Kenji

  Department Of Chemistry Faculty Of Science Tohoku University

• Fujiwara Tomoya

  Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceutical University

• Fujisawa Hidehito

  Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceutical University

• Takeuchi Yoshio

  Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceutical University

• Takeuchi Yoshio

  Faculty Of Pharmaceutical Sciences Toyama Medical & Pharmaceutical University

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