海馬CA1野のカオス時系列刺激依存性長期増強(LTP)

概要

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In our previous report (Tsukada et al. (1996): Neural Networks, Vol. 9, pp. 1357-1365), the temporal pattern sensitivity of long-term potentiation (LTP) in hippocampal CA1 neurons was estimated by using Markov chain stimuli with different values of the serial correlation coefficient ρ1 between successive interstimulus-intervals. In this paper, the effect of chaotic stimuli on induction of LTP in the hippocampal CA1 area was investigated in comparison with those of Markov chain stimuli and periodic stimuli. The chaotic stimuli were produced by a modified Bernoulli map, so that interstimulus sequences with various values of ρ1 can be generated by changing the parameter B. These stimuli had an identical first order statistics (mean interstimulus-interval and variance), but their higher order statistics were different in the serial correlation coefficient as well as in fluctuation regarding the dynamic property of stimulus sequences. The LTP induced by chaotic stimuli with B=2 were significantly larger in magnitude than those of periodic stimuli and Markov chain stimuli, and also depended on the initial value of chaotic stimulus at B=2 and 3. These results suggest that chaotic signals play an important role for memory coding in the hippocampal CA1 network, and are discussed in relation to findings from a model simulation.
日本神経回路学会の論文
1999-06-05