Detection of Zearalenone Using a Metal–Oxide–Semiconductor Field-Effect-Transistor-Based Biosensor Employing a Pt Reference Electrode

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概要

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• We have fabricated a metal–oxide–semiconductor field-effect-transistor (MOSFET)-based biosensor for the detection of zearalenone using a standard complementary metal–oxide–semiconductor (CMOS) process. Au was used as the gate metal to immobilize a self-assembled monolayer (SAM) made of mercaptohexadecanoic acid (MHDA). The SAM was used to immobilize anti-zearalenone antibody. The carboxyl group of the SAM was bound to the anti-zearalenone antibody. Anti-zearalenone antibody and zearalenone were bound by an antigen-antibody reaction. The measurements were performed in phosphate buffered saline (PBS; pH 7.4) solution. A Pt electrode was employed as a reference electrode. The gate voltage of the sensor was applied using the Pt reference electrode. The binding of the SAM, anti-zearalenone antibody, and zearalenone caused a variation in the drain current of the MOSFET-based biosensor. To verify the interaction among the SAM, anti-zearalenone antibody, and zearalenone, surface plasmon resonance (SPR) measurements were performed.

• 2009-06-25

著者

• Shin Jang-kyoo

  School Of Electrical Engineering And Computer Science Kyungpook National University

• Seo Sang-ho

  School Of Electrical Engineering And Computer Science Kyungpook National University

• CHUN Hyang

  Korea Food Research Institute

• Shin Jang-Kyoo

  School of Electrical Engineering and Computer Science, Kyungpook National University, 1370 Sankyuk-dong, Buk-ku, Daegu 702-701, Korea

• Seo Sang-Ho

  School of Electrical Engineering and Computer Science, Kyungpook National University, 1370 Sankyuk-dong, Buk-ku, Daegu 702-701, Korea

• Lim Byounghyun

  School of Electrical Engineering and Computer Science, Kyungpook National University, 1370 Sankyuk-dong, Buk-ku, Daegu 702-701, Korea

• Cho Byunghyun

  School of Electrical Engineering and Computer Science, Kyungpook National University, 1370 Sankyuk-dong, Buk-ku, Daegu 702-701, Korea

• Choi Ho-Jin

  School of Electrical Engineering and Computer Science, Kyungpook National University, 1370 Sankyuk-dong, Buk-ku, Daegu 702-701, Korea

• Choi Sung-Wook

  Korea Food Research Institute, San 46-1, Backhyun-dong, Bundang-gu, Sungnam, Kyonggi-do 463-746, Korea

• Choi Sung-Wook

  Korea Food Research Institude, Sungnam, Kyonggi-do 463-746, Korea

• Chun Hyang

  Korea Food Research Institute, San 46-1, Backhyun-dong, Bundang-gu, Sungnam, Kyonggi-do 463-746, Korea

• Chun Hyang

  Korea Food Research Institude, Sungnam, Kyonggi-do 463-746, Korea

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