Developing Platform for Detecting Biomolecules

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概要

• 論文の詳細を見る

• Using optical interference of reflected lights from interfaces, a multilayer structure was designed to make a label-free biosensor. This optical system is quite similar to the commercial digital versatile disc (DVD) drive, and reflection intensity was determined by an optimized polycarbonate disc consisting of five layers of Au (5 nm)/(ZnS)85(SiO2)15 (85 nm)/Ag6.0In4.4Sb61.0Te28.6 (15 nm)/(ZnS)85(SiO2)15 (45 nm)/Au (50 nm). Using this multilayered structure, we monitored a DNA hybrid as an application to the field of biology. Considering various issues for developing a suitable platform for detecting biomolecular interactions on this BioDVD, phase shifting alloys used in this system will facilitate the addressing biomolecules. Furthermore, for high-throughput analysis, we proposed the spotting method to attach several molecules to different tracks of BioDVD.

• 2008-07-25

著者

• Kumar Penmetcha

  Functional Nucleic Acids Group Institute For Biological Resources And Functions National Institute O

• Tominaga Junji

  Center for Applied Near Field Optics Research (CAN-FOR), National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba, Ibaraki 305-8562, Japan

• Awazu Koichi

  Center for Applied Near Field Optics Research (CAN-FOR), National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba, Ibaraki 305-8562, Japan

• Kumar Penmetcha

  Functional Nucleic Acids Group, Institute for Biological Resources and Functions, National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba, Ibaraki 305-8566, Japan

• Arai Tomofumi

  Center for Applied Near Field Optics Research (CAN-FOR), National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba, Ibaraki 305-8562, Japan

• Gopinath Subash

  Center for Applied Near Field Optics Research (CAN-FOR), National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba, Ibaraki 305-8562, Japan

• Mizuno Hiroshi

  Functional Nucleic Acids Group, Institute for Biological Resources and Functions, National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba, Ibaraki 305-8566, Japan

関連論文

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