Broncasma Berna®下気道への影響-組織学的・免疫学的検討

概要

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Female Hartley guinea pigs (SPF) were divided into three groups. In the first group, Broncasma Berna®(B. B. ) solution was administered by Jet nebulization every day for one week and this treatment was repeated after an interval of seven days during a four-week period. In the second group,0.4% phenolsolution was administered acccording to the same schedule as the first group. The third group was the control group which received no treatment.<BR>Histologically, the lower airway did not show any changes suggesting inflammation such as bronchitis following the administration of B. B. Anti-B. B. antibody could not be clearly detected either in serum or in bronchial washing by ELISA or PCA reaction.<BR>On the other hand, the cells from paratracheal lymph nodes in the first gro u p exhibited a higher response to PHA than those in the other groups. Also, the culture medium of lung macrophages enhanced the proliferation of the fibroblasts.<BR>The in vitro study with human blood leukoc y tes or with normal human nasal mucosa, enhanced expression of TNF a was observed after the administration of B. B.<BR>These findings suggest that B. B. inhalation with Jet nebulization is safe a nd that B. B. influences the products of TNF a in the nasal mucosa.
耳鼻咽喉科臨床学会の論文