L-AMPCの扁桃組織内移行および耳鼻咽喉科領域感染症に対する臨床効果

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The transfer of L-AMPC, a new, long-acting preparation of amoxicillin, into the tissue of the faucial tonsils was investigated in 11 patients undergoing tonsillectomy.The concentrations of the drug after single oral administration of 500mg were 0.22-0.37μg/g at 60-150mins. in 4 of 5 subjects, 0.12-0.24μg/g at 275-345mins. in 3 of 6 subjects.L-AMPC was orally administered to 23 patients with upper respiratory tract infection at daily doses of 1000mg (b. i. d.) for 7 days. Clinical response was excellent in 6, good in 13, fair in 3 and poor in 1, and the effective rate was 82.6%. No side effects were observed.