内耳におけるメラニンの分布と分析

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In order to study distribution of the melanin and melanocytes in the inner ear, we used 10 crucians (fresh-water fish),10 frogs,5 guinea pigs and human.<BR>Melanin and melanocytes were distributed mostly in the crus com m une and ampulla of frog, and in the ampulla and utricle of guinea pig. The shape of melanocyte was dendritic in crusian and frog, whereas it was rod shape in the guinea pig which was similar to melanocyte in pia mater of human.<BR>Histologically, we observed these species by H-E staining, melanocytes in guinea pig and human were localized adjacent to the epithelium of ampulla, while these in crucian and frog were localized in the surroundings of ampulla in some distance from the epithelium.<BR>We, using microanalysis by Ito, measured the contents of PTCA (indicator of eumelanin) and AHP (indicator of pheomelanin) in membranous labyrinth of utricules and posterior ampullae from 8 colored and 5 albino guinea pigs.<BR>The mean content of PTCA and AHP membranous labyr i n th were 10.1 ng per ear and 1.8 ng per ear respectively in colored guinea pigs, while 0.3 ng per ear and 4.6 ng per ear in albino guinea pigs. Eumelanin content of inner ear in the colored guinea pig was dominantly higher than that of the black hair in colored guinea pig or Japanese.
耳鼻咽喉科臨床学会の論文